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SB-258585
CAS No. 209480-63-7
SB-258585 ( SB258585 )
Catalog No. M13292 CAS No. 209480-63-7
SB-258585 is a potent, selective and orally active 5-HT6 receptor antagonist with Ki of 8.9 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 86 | Get Quote |
|
| 10MG | 147 | Get Quote |
|
| 25MG | 264 | Get Quote |
|
| 50MG | 464 | Get Quote |
|
| 100MG | 664 | Get Quote |
|
| 500MG | 1377 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSB-258585
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NoteResearch use only, not for human use.
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Brief DescriptionSB-258585 is a potent, selective and orally active 5-HT6 receptor antagonist with Ki of 8.9 nM.
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DescriptionSB-258585 is a potent, selective and orally active 5-HT6 receptor antagonist with Ki of 8.9 nM, >160-fold selectivity over other 5-HT receptor subtypes; also is an inhibitor of HCV entry in liver-derived cell lines as well as primary hepatocytes, modulates localization of the coreceptor tight junction protein claudin-1 (CLDN1) in a 5-HT6-independent manner, induces intracellular accumulation of CLDN1.
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SynonymsSB258585
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number209480-63-7
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Formula Weight487.36
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Molecular FormulaC18H22IN3O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=S(C1=CC=C(I)C=C1)(NC2=CC=C(OC)C(N3CCN(C)CC3)=C2)=O.[H]Cl
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Chemical Name4-Iodo-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]benzenesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hirst WD, et al. Br J Pharmacol. 2000 Aug;130(7):1597-605.
2. Riva L, et al. J Virol. 2018 Apr 27;92(10). pii: e01982-17.
2. Riva L, et al. J Virol. 2018 Apr 27;92(10). pii: e01982-17.
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