SB-258585 ( SB258585 )

Catalog No. M13292 CAS No. 209480-63-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SB-258585
Note

Research use only, not for human use.
Brief Description

SB-258585 is a potent, selective and orally active 5-HT6 receptor antagonist with Ki of 8.9 nM.
Description

SB-258585 is a potent, selective and orally active 5-HT6 receptor antagonist with Ki of 8.9 nM, >160-fold selectivity over other 5-HT receptor subtypes; also is an inhibitor of HCV entry in liver-derived cell lines as well as primary hepatocytes, modulates localization of the coreceptor tight junction protein claudin-1 (CLDN1) in a 5-HT6-independent manner, induces intracellular accumulation of CLDN1.
Synonyms

SB258585
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

5-HT Receptor
Research Area

——
Indication

——

CAS Number

209480-63-7
Formula Weight

487.36
Molecular Formula

C18H22IN3O3S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=S(C1=CC=C(I)C=C1)(NC2=CC=C(OC)C(N3CCN(C)CC3)=C2)=O.[H]Cl
Chemical Name

4-Iodo-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]benzenesulfonamide

1. Hirst WD, et al. Br J Pharmacol. 2000 Aug;130(7):1597-605.
2. Riva L, et al. J Virol. 2018 Apr 27;92(10). pii: e01982-17.

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