SB-200646

CAS No. 143797-63-1

SB-200646( —— )

Catalog No. M21616 CAS No. 143797-63-1

SB-200646 is a selective and potent?antagonist of 5-HT2B/5-HT2C receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 138 Get Quote
5MG 196 Get Quote
10MG 295 Get Quote
25MG 498 Get Quote
50MG 716 Get Quote
100MG 981 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    SB-200646
  • Note
    Research use only, not for human use.
  • Brief Description
    SB-200646 is a selective and potent?antagonist of 5-HT2B/5-HT2C receptor.
  • Description
    SB-200646 is a selective and potent?antagonist of 5-HT2B/5-HT2C receptor.
  • In Vitro
    SB-200646A (4 μM) abolishes the ethanol-induced increase in miniature inhibitory postsynaptic current (mIPSC) frequency and had no effect on basal mIPSC frequency.
  • In Vivo
    SB-200646A (20 mg/kg; intravenous injection; daily; for 21 days; male albino Sprague-Dawley rats) treatment significantly decreases the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons.The i.v. administration of 4-16 mg/kg of SB-200646A significantly increases the firing rate and % events as bursts in spontaneously active VTA dopaminergic neurons and significantly increases the % events as burst in substantia nigra pars compacta (SNC) dopaminergic neurons. Animal Model:Male albino Sprague-Dawley rats (200-225 g at the beginning of treatment and 300-350 g at the time of the experiment)Dosage:20 mg/kg Administration:Intravenous injection; daily; for 21 days Result:Significantly decreased the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT2B|5-HT2C
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    143797-63-1
  • Formula Weight
    266.3
  • Molecular Formula
    C15H14N4O??
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:53 mg/mL (199.02 mM)
  • SMILES
    Cn1ccc2cc(NC(=O)Nc3cccnc3)ccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kennett GA et al. In vivo properties of SB 200646A a 5-HT2C/2B receptor antagonist. Br J Pharmacol. 1994 Mar;111(3):797-802.
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