
SB-200646
CAS No. 143797-63-1
SB-200646( —— )
Catalog No. M21616 CAS No. 143797-63-1
SB-200646 is a selective and potent?antagonist of 5-HT2B/5-HT2C receptor.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 138 | Get Quote |
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5MG | 196 | Get Quote |
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10MG | 295 | Get Quote |
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25MG | 498 | Get Quote |
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50MG | 716 | Get Quote |
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100MG | 981 | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameSB-200646
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NoteResearch use only, not for human use.
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Brief DescriptionSB-200646 is a selective and potent?antagonist of 5-HT2B/5-HT2C receptor.
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DescriptionSB-200646 is a selective and potent?antagonist of 5-HT2B/5-HT2C receptor.
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In VitroSB-200646A (4 μM) abolishes the ethanol-induced increase in miniature inhibitory postsynaptic current (mIPSC) frequency and had no effect on basal mIPSC frequency.
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In VivoSB-200646A (20 mg/kg; intravenous injection; daily; for 21 days; male albino Sprague-Dawley rats) treatment significantly decreases the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons.The i.v. administration of 4-16 mg/kg of SB-200646A significantly increases the firing rate and % events as bursts in spontaneously active VTA dopaminergic neurons and significantly increases the % events as burst in substantia nigra pars compacta (SNC) dopaminergic neurons. Animal Model:Male albino Sprague-Dawley rats (200-225 g at the beginning of treatment and 300-350 g at the time of the experiment)Dosage:20 mg/kg Administration:Intravenous injection; daily; for 21 days Result:Significantly decreased the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons.
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Synonyms——
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT2B|5-HT2C
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Research Area——
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Indication——
Chemical Information
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CAS Number143797-63-1
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Formula Weight266.3
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Molecular FormulaC15H14N4O??
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Purity>98% (HPLC)
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SolubilityDMSO:53 mg/mL (199.02 mM)
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SMILESCn1ccc2cc(NC(=O)Nc3cccnc3)ccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Kennett GA et al. In vivo properties of SB 200646A a 5-HT2C/2B receptor antagonist. Br J Pharmacol. 1994 Mar;111(3):797-802.
molnova catalog



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