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SAR439859

CAS No. 2114339-57-8

SAR439859 ( —— )

Catalog No. M23964 CAS No. 2114339-57-8

SAR439859 is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SAR439859
  • Note
    Research use only, not for human use.
  • Brief Description
    SAR439859 is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD).
  • Description
    SAR439859 is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD). SAR439859 is a potent antagonist of ER (with an EC50 of 0.2 nM for ERα degradation).
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    Estrogen Receptor/ERR
  • Recptor
    ERα
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2114339-57-8
  • Formula Weight
    554.5
  • Molecular Formula
    C31H30Cl2FNO3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL?(225.44 mM;?Need ultrasonic)
  • SMILES
    C1CC2=C(C=CC(=C2)C(=O)O)C(=C(C1)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)O[C@H]5CCN(C5)CCCF
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.El-Ahmad Y, et al. Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer. J Med Chem. 2019 Nov 27.
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