S100P-IN-1

Research use only, not for human use.

S100P-IN-1 is a potent S100P inhibitor.S100P-IN-1 has anti-metastatic effects on pancreatic cancer (pancreatic) cells.

S100P-IN-1 (Compound 4) is a S100P inhibitor with an IC50 of 22.7 nM. S100P-IN-1 shows anti-metastatic effects on pancreatic cancer cells.

S100P-IN-1 (Compound 4) blocks S100P binding to RAGE in a dose dependent manner.S100P-IN-1 (10 μM, 24 h) shows S100P-specific inhibitory effect on cell invasion, without obvious cytotoxicity..Cell Invasion Assay Cell Line:Human pancreatic cancer cell lines PanC-1 (ATCC- CRL-1469), and BxPC-3 (ATCC-CRL-1687)Concentration:10 μM Incubation Time:48 h Result:Significantly inhibited invasion to the lower chamber in BxPC-3 cells, but didn’t inhibit invasion of PanC-1 (lack S100P expression) cells.Cell Viability Assay Cell Line:BxPC-3 and Panc-1 cells Concentration:10 μM Incubation Time:24 h Result:Showed no significant effect on cell metabolic activity and cytotoxicity in either cell line.

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Others

Other Targets

Others

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690991-06-1

440.4

C25H16N2O6

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (227.07 mM; Ultrasonic )

O=C(O)C1=CC=CC(=C1)N2C(=O)C3C4C=5C=CC=CC5C(C=6C=CC=CC64)(N(=O)=O)C3C2=O

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(-20℃)

With Ice Pack

≥ 2 years