S0859( S0859 | S-0859 | S 0859. )

Catalog No. M10093 CAS No. 1019331-10-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

S0859
Note

Research use only, not for human use.
Brief Description

S0859, an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery.
Description

S0859, an N-cyanosulphonamide compound, reversibly inhibit NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM).
In Vitro

Treatment with NBC inhibitor S0859 significantly increased caspase-3 activity and elevated the number of apoptotic EC. S0859 is potentially important for probing the transporter's functional role in heart and other tissues.
In Vivo

——
Synonyms

S0859 | S-0859 | S 0859.
Pathway

Others
Target

Other Targets
Recptor

NBC
Research Area

Cardiovascular Disease
Indication

——

CAS Number

1019331-10-2
Formula Weight

530.04
Molecular Formula

C29H24ClN3O3S
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM
SMILES

O=C(N(CC1=CC=C(C2=CC=CC=C2S(=O)(NC#N)=O)C=C1)CC3=CC=C(C)C=C3)C4=CC=CC=C4Cl
Chemical Name

2-chloro-N-((2'-(N-cyanosulfamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(4-methylbenzyl)benzamide

1.Larsen AM, et al. ChemMedChem. 2012 Oct;7(10):1808-14.

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