S-Gboxin( —— )

Catalog No. M20091 CAS No. 2101317-21-7

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Datasheet

HNMR

HPLC

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Product Name

S-Gboxin
Note

Research use only, not for human use.
Brief Description

S-Gboxin is an active analogue of Gboxin with potent antitumour activity. S-Gboxin inhibits the growth of mouse and human glioblastoma (GBM IC50: 470 nM).
Description

S-Gboxin is an active analogue of Gboxin with potent antitumour activity. S-Gboxin inhibits the growth of mouse and human glioblastoma (GBM IC50: 470 nM).
In Vitro

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In Vivo

S-Gboxin retains excellent metabolic stability, enhanced plasma stability, and PK-propertiessuitable for in vivo studies. S-Gboxin (10 mg/kg/day; intraperitoneally) inhibits glioblastoma (GBM) growth in vivo. Animal Model:Female nude mice (6 to 9 weeks)Dosage:10 mg/kg/day Administration:Administered intraperitoneally; daily; 3 or 14 days Result:Resulted in significant attenuation of growth and decreased cellular density compared to controls.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

CAS Number

2101317-21-7
Formula Weight

600.46
Molecular Formula

C27H32F3IN2O2
Purity

>98% (HPLC)
Solubility

DMSO: 85 mg/mL (141.56 mM)
SMILES

[I-].CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)Cn1c(-c2cccc(c2)C(F)(F)F)[n+](C)c2ccccc12
Chemical Name

——

1.Shi Y et al. Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma. Nature. 2019 Mar;567(7748):341-346.

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