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Rupintrivir
CAS No. 223537-30-2
Rupintrivir( AG-7088 | AG7088 )
Catalog No. M13584 CAS No. 223537-30-2
Rupintrivir (AG-7088, AG7088) is a potent, irreversible inhibitor of human rhinovirus 3C protease, inhibits the replication of all HRV serotypes with EC50 of 23 nM and EC90 of 82 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 258 | Get Quote |
|
| 50MG | 1071 | Get Quote |
|
| 100MG | 1611 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameRupintrivir
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NoteResearch use only, not for human use.
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Brief DescriptionRupintrivir (AG-7088, AG7088) is a potent, irreversible inhibitor of human rhinovirus 3C protease, inhibits the replication of all HRV serotypes with EC50 of 23 nM and EC90 of 82 nM.
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DescriptionRupintrivir (AG-7088, AG7088) is a potent, irreversible inhibitor of human rhinovirus 3C protease, inhibits the replication of all HRV serotypes with EC50 of 23 nM and EC90 of 82 nM; potently and irreversibly inhibits HRV 3C protease with an inactivation rate constant (kobs/[I]) of 1,470,000 ± 440,000 M-1 s-1 for HRV 14; also potently inhibits related picornaviruses including coxsackieviruses A21 and B3, enterovirus 70, and echovirus 11.Rhinovirus Infection Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsAG-7088 | AG7088
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PathwayMicrobiology/Virology
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TargetRhinovirus
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RecptorRhinovirus
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Research AreaInfection
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IndicationRhinovirus Infection
Chemical Information
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CAS Number223537-30-2
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Formula Weight598.672
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Molecular FormulaC31H39FN4O7
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (83.52 mM)
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SMILESO=C(OCC)/C=C/[C@@H](NC([C@H](CC1=CC=C(F)C=C1)CC([C@@H](NC(C2=NOC(C)=C2)=O)C(C)C)=O)=O)C[C@H]3C(NCC3)=O
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Chemical NameEthyl (2E,4S)-4-[[(2R,5S)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-1,4-dioxoheptyl]amino]-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Patick AK, et al. Antimicrob Agents Chemother. 1999 Oct;43(10):2444-50.
2. Dragovich PS, et al. J Med Chem. 1999 Apr 8;42(7):1213-24.
3. Matthews DA, et al. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11000-7.
4. Zalman LS, et al. Antimicrob Agents Chemother. 2000 May;44(5):1236-41.
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Rupintrivir
Rupintrivir (AG-7088, AG7088) is a potent, irreversible inhibitor of human rhinovirus 3C protease, inhibits the replication of all HRV serotypes with EC50 of 23 nM and EC90 of 82 nM.
