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Roy-Bz

CAS No. 1246304-91-5

Roy-Bz( PKCδ activator Roy-Bz )

Catalog No. M10997 CAS No. 1246304-91-5

Roy-Bz is the?first?small-molecule?PKCδ-selective activator with EC50 of 58.5 nM, binds to the PKCδ-C1-domain.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Roy-Bz
  • Note
    Research use only, not for human use.
  • Brief Description
    Roy-Bz is the?first?small-molecule?PKCδ-selective activator with EC50 of 58.5 nM, binds to the PKCδ-C1-domain.
  • Description
    Roy-Bz is the?first?small-molecule?PKCδ-selective activator with EC50 of 58.5 nM, binds to the PKCδ-C1-domain; displays no activity against human cPKCs (a mix of PKCα, β, and γ), nPKCδ, nPKCε and aPKCζ; potently inhibits the proliferation of colon cancer cells (HCT116 IC50=0.58 uM) by inducing a PKCδ-dependent mitochondrial apoptotic pathway involving caspase-3 activation; demonstrates PKCδ-dependent antitumor effect, through anti-proliferative, pro-apoptotic, and anti-angiogenic activities in xenograft mouse models with no apparent toxic side effects.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PKCδ activator Roy-Bz
  • Pathway
    Angiogenesis
  • Target
    PKC
  • Recptor
    PKC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1246304-91-5
  • Formula Weight
    598.692
  • Molecular Formula
    C36H38O8
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(OC1=C(C(C)C)C(C([C@H](OC(C)=O)[C@@H](OC(C2=CC=CC=C2)=O)[C@@H](C(C)(C)CCC3)[C@@]43C)=C4C1=O)=O)C5=CC=CC=C5
  • Chemical Name
    (4bS,8aS,10S)-10-acetoxy-2-isopropyl-4b,8,8-trimethyl-1,4-dioxo-1,4,4b,5,6,7,8,8a,9,10-decahydrophenanthrene-3,9-diyl dibenzoate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bessa C, et al. Cell Death Dis. 2018 Jan 18;9(2):23.
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