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Ropinirole

CAS No. 91374-21-9

Ropinirole( —— )

Catalog No. M35416 CAS No. 91374-21-9

Ropinirole (SKF 101468) is a selective D2-like family receptor agonist whereas it has no affinity for the D1 receptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ropinirole
  • Note
    Research use only, not for human use.
  • Brief Description
    Ropinirole (SKF 101468) is a selective D2-like family receptor agonist whereas it has no affinity for the D1 receptors.
  • Description
    Ropinirole (SKF 101468) is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole has no affinity for the D1 receptors. Ropinirole has the potential for Parkinson's disease.
  • In Vitro
    Ropinirole has affinity for D3 receptors of 10-20 fold higher than the D2 and D4 receptors. Ropinirole is weakly active at alpha 2-adrenoceptors and 5-HT2 receptors but inactive at 5-HT1, benzodiazepine and gamma-aminobutyric acid receptors or alpha 1 and beta-adrenoceptors.
  • In Vivo
    Ropinirole (0.1-10 mg/kg; i.p.) decreases intracranial self-stimulation (ICSS) thresholds and induces anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    91374-21-9
  • Formula Weight
    260.37
  • Molecular Formula
    C16H24N2O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(CN(CCC)CCC)C1=C2C(NC(=O)C2)=CC=C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Eden, R.J., et al., Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol Biochem Behav, 1991. 38(1): p. 147-54.?
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