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Ronacaleret

CAS No. 753449-67-1

Ronacaleret( SB-751689 | SB751689 )

Catalog No. M15865 CAS No. 753449-67-1

A potent calcium sensing receptor (CaSR) negative allosteric modulator with IC50 of 146 nM for hCaSR.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ronacaleret
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent calcium sensing receptor (CaSR) negative allosteric modulator with IC50 of 146 nM for hCaSR.
  • Description
    A potent calcium sensing receptor (CaSR) negative allosteric modulator with IC50 of 146 nM for hCaSR; stimulates parathyroid hormone (PTH) release and increases bone formation markers; act as an effective oral anabolic agent to enhance fracture healing.Osteoporosis Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    SB-751689 | SB751689
  • Pathway
    GPCR/G Protein
  • Target
    CaSR
  • Recptor
    CaSR
  • Research Area
    Metabolic Disease
  • Indication
    Osteoporosis

Chemical Information

  • CAS Number
    753449-67-1
  • Formula Weight
    447.523
  • Molecular Formula
    C25H31F2NO4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)(CC1CC2=CC=CC=C2C1)NCC(COC3=C(C(=CC(=C3)CCC(=O)O)F)F)O
  • Chemical Name
    3-[3-[(2R)-3-[[1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]-4,5-difluorophenyl]propanoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Balan G, et al. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3328-32. 2. Fitzpatrick LA, et al. J Clin Endocrinol Metab. 2011 Aug;96(8):2441-9. 3. Fitzpatrick LA, et al. Bone. 2011 Oct;49(4):845-52. 4. Caltabiano S, et al. Bone. 2013 Sep;56(1):154-62.
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