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Ro0711401
CAS No. 714971-87-6
Ro0711401( Ro-0711401 | Ro 0711401 )
Catalog No. M24725 CAS No. 714971-87-6
Ro0711401 is an agonist of mGlu1 receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 67 | In Stock |
|
| 5MG | 110 | In Stock |
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| 10MG | 177 | In Stock |
|
| 25MG | 410 | In Stock |
|
| 50MG | 605 | In Stock |
|
| 100MG | 860 | In Stock |
|
| 500MG | 1728 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRo0711401
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NoteResearch use only, not for human use.
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Brief DescriptionRo0711401 is an agonist of mGlu1 receptor.
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DescriptionRo0711401 is an agonist of mGlu1 receptor.
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In Vitro——
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In VivoRO0711401 (10 mg/kg; s.c.; once) causes a long-lasting improvement in motor performance, which is maintained to the same extent at least for 6 days.Systemic injection of RO0711401 is shown to reduce the frequency of spike-and-wave discharges in a rat model of absence epilepsy, and to improve motor signs in autoimmune encephalomyelitis (EAE) mice. Animal Model:Spinocerebellar ataxia type 1 (SCA1) mice (30-week old) Dosage:10 mg/kg Administration:Subcutaneous injection; once Result:Caused a prolonged improvement of motor performance on the rotarod and the paw-print tests.
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SynonymsRo-0711401 | Ro 0711401
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PathwayNeuroscience
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TargetGluR
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RecptormGluR1
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Research Area——
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Indication——
Chemical Information
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CAS Number714971-87-6
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Formula Weight360.29
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Molecular FormulaC18H11F3N2O3
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Purity>98% (HPLC)
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SolubilityDMSO : 100 mg/mL (277.55 mM; Need ultrasonic)
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SMILESO=C(C1C2=C(OC3=C1C=CC=C3)C=CC=C2)NC4=NC(C(F)(F)F)=CO4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.D'Amore V, Santolini I, Celli R, Lionetto L, De Fusco A, Simmaco M, van Rijn CM, Vieira E, Stauffer SR, Conn PJ, Bosco P, Nicoletti F, van Luijtelaar G, Ngomba RT. Head-to head comparison of mGlu1 and mGlu5 receptor activation in chronic treatment of absence epilepsy in WAG/Rij rats. Neuropharmacology. 2014 Oct;85:91-103. doi: 10.1016/j.neuropharm.2014.05.005. E
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