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Riociguat

CAS No. 625115-55-1

Riociguat ( BAY 63-2521; BAY63-2521; Riociguat )

Catalog No. M18919 CAS No. 625115-55-1

Riociguat is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hypertension.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 54 In Stock
10MG 86 In Stock
25MG 149 In Stock
50MG 227 In Stock
100MG 389 In Stock
500MG 884 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Riociguat
  • Note
    Research use only, not for human use.
  • Brief Description
    Riociguat is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle and is used to treat severe pulmonary arterial hypertension.
  • Description
    Riociguat, also known as BAY 63-2521, is a novel drug that is currently in clinical development by Bayer. It is a stimulator of soluble guanylate cyclase (sGC). At the moment Phase III clinical trials investigate the use of riociguat as a new approach to treat two forms of pulmonary hypertension (PH): chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH). Riociguat constitutes the first drug of a novel class of sGC stimulators.
  • Synonyms
    BAY 63-2521; BAY63-2521; Riociguat
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Guanylate cyclase
  • Research Area
    Cardiovascular Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    625115-55-1
  • Formula Weight
    422.42
  • Molecular Formula
    C20H19FN8O2
  • Purity
    98%
  • Solubility
    DMSO : ≥ 50 mg/mL; 118.37 mM
  • SMILES
    C(=O)(N(C)c1c(nc(nc1N)c1c2c(nccc2)n(n1)Cc1c(cccc1)F)N)OC
  • Chemical Name
    methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Schermuly RT, et al. Eur Respir J. 2008, 32(4), 881-891.
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