Resveratrol

CAS No. 501-36-0

Resveratrol( (E)-Resveratrol )

Catalog No. M14685 CAS No. 501-36-0

Resveratrol is a phytoalexin produced naturally by several plants with anti-Y, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
50MG 27 In Stock
100MG 32 In Stock
200MG 45 In Stock
500MG 68 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Resveratrol
  • Note
    Research use only, not for human use.
  • Brief Description
    Resveratrol is a phytoalexin produced naturally by several plants with anti-Y, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.
  • Description
    Resveratrol is a phytoalexin produced naturally by several plants with anti-Y, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects.(In Vitro):Resveratrol (trans-Resveratrol; SRT501) is one of the numerous polyphenolic compounds found in several vegetal sources In the vast majority of cases, Resveratrol displays inhibitory/activatory effects in the micromolar range, which is potentially attainable pharmacologically, although targets with affinities in the nanomolar range have also been reported.MCF-7 cells are plated in DME-F12 medium supplemented with 5% FBS in the presence of increasing concentrations of Resveratrol. Control cells are treated with the same volume of vehicle only (0.1% ethanol). Resveratrol inhibits the growth of MCF-7 cells in a dose-dependent fashion. Addition of 10 μM Resveratrol results in an 82% inhibition of MCF-7 cell growth after 6 days while at 1 μM, only a 10% inhibition is observed. The cells treated with 10 μM Resveratrol have a doubling time of 60 hr whereas control cells doubled every 30 hr. Trypan blue exclusion assay shows that at concentrations of 10 μM or lower, Resveratrol does not affect cell viability (90% viable cells) whereas at 100 μM, only 50% of the cells are viable after 6 days of Resveratrol treatment. Moreover, MCF-7 cells do not undergo apoptosis after incubation with Resveratrol at concentration of 10 μM as determined by ApoAlert Annexin V Apoptosis kit.Resveratrol increases the production of nitric oxide (NO) in endothelial cells by upregulating the expression of endothelial NO synthase (eNOS), stimulating eNOS enzymatic activity, and preventing eNOS uncoupling. (In Vivo):The average tumor volume is reduced by treatment with Resveratrol (trans-Resveratrol; SRT501) at a dose of 50 mg/kg body weight (195.5±124.8 mm3; P<0.05) or 100 mg/kg body weight (81.7±70.5 mm3; P<0.001) compare with the vehicle-treated animals (315±94 mm3). There is a good correlation between the tumor volume and the tumor mass.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    (E)-Resveratrol
  • Pathway
    Chromatin/Epigenetic
  • Target
    COX
  • Recptor
    COX-1| COX-2| DNA polymerase α| IKKβ| LOX| Quinone reductase 2| SIRT1| SIRT2
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    501-36-0
  • Formula Weight
    228.24
  • Molecular Formula
    C14H12O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 45 mg/mL warmed (197.16 mM)
  • SMILES
    OC1=CC(/C=C/C2=CC=C(O)C=C2)=CC(O)=C1
  • Chemical Name
    (E)-5-(4-hydroxystyryl)benzene-1,3-diol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Pirola L, et al. IUBMB Life, 2008, 60(5), 323-332.
molnova catalog
related products
  • (R)-Flurbiprofen

    A non-steroidal anti-inflammatory drug (NSAID); primarily indicated as a pre-operative anti-miotic as well as orally for arthritis or dental pain; cyclooxygenase (COX) inhibitor.

  • Zaltoprofen

    Zaltoprofen is an inhibitor of Cox-1 and Cox-2 for treatment of arthritis.

  • Cimicoxib

    Cimicoxib is a potent and selective inhibitor of COX-2 with anti-inflammatory and analgesic activity.