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Relacorilant

CAS No. 1496510-51-0

Relacorilant ( CORT 125134 )

Catalog No. M23647 CAS No. 1496510-51-0

Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Relacorilant
  • Note
    Research use only, not for human use.
  • Brief Description
    Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor.
  • Description
    Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor(Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively). Relacorilant has the potential for Cushing’s syndrome treatment.
  • Synonyms
    CORT 125134
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Glucocorticoid receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1496510-51-0
  • Formula Weight
    586.6
  • Molecular Formula
    C27H22F4N6O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:10 mM
  • SMILES
    CN1C=C(C=N1)S(=O)(=O)N2CCC3=CC4=C(C[C@@]3(C2)C(=O)C5=NC=CC(=C5)C(F)(F)F)C=NN4C6=CC=C(C=C6)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hunt HJ, et al. Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist. J Med Chem. 2017 Apr 27;60(8):3405-3421.
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