Relacorilant ( CORT 125134 )

Catalog No. M23647 CAS No. 1496510-51-0

Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor.

Purity : >98% (HPLC)

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Biological Information

Product Name

Relacorilant
Note

Research use only, not for human use.
Brief Description

Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor.
Description

Relacorilant is a selective and orally bioavailable antagonist of glucocorticoid receptor(Ki of 7.2 nM in HepG2 TAT assay, and also shows Kis of 12, 81.2, 210 nM for rat, human and monkey glucocorticoid receptor in cell-based assay, respectively). Relacorilant has the potential for Cushing’s syndrome treatment.
Synonyms

CORT 125134
Pathway

Others
Target

Other Targets
Recptor

Glucocorticoid receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

1496510-51-0
Formula Weight

586.6
Molecular Formula

C27H22F4N6O3S
Purity

>98% (HPLC)
Solubility

DMSO:10 mM
SMILES

CN1C=C(C=N1)S(=O)(=O)N2CCC3=CC4=C(C[C@@]3(C2)C(=O)C5=NC=CC(=C5)C(F)(F)F)C=NN4C6=CC=C(C=C6)F
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Hunt HJ, et al. Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist. J Med Chem. 2017 Apr 27;60(8):3405-3421.

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