Rasarfin

CAS No. 674359-73-0

Rasarfin ( —— )

Catalog No. M28668 CAS No. 674359-73-0

Rasarfin inhibits Ras and ARF6.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 71 Get Quote
5MG 110 Get Quote
10MG 177 Get Quote
25MG 323 Get Quote
50MG 537 Get Quote
100MG 767 Get Quote
500MG 1557 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Rasarfin
  • Note
    Research use only, not for human use.
  • Brief Description
    Rasarfin inhibits Ras and ARF6.
  • Description
    Rasarfin inhibits Ras and ARF6.(In Vitro):Rasarfin resulted in a dose-dependent reduction in cell growth in MDA-MB-231 cells.After 48 and 72?h of treatment, Rasarfin modestly decreased in a dose-dependent manner the metabolic activity of cancer cells compared to cells treated with DMSO.However, compared to Doxorubicin which potently killed cells, cell viability was not affected by Rasarfin treatment. Rasarfin inhibited proliferation of A549 lung cancer cells, which have increased Ras and EGFR activity52. Similar to the anti-proliferative effect on MDA-MB-231 cells, A549 cell growth inhibition at 5 and 10?μM of Rasarfin,more important cell viability effects of Rasarfin on A549 cells than MDA-MB-231 cells at 10?μM of Rasarfin treatment.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    EGFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    674359-73-0
  • Formula Weight
    425.9
  • Molecular Formula
    C23H24ClN3O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)C(N(CC1)CCN1c(ccc(NC(c1cc(cccc2)c2o1)=O)c1)c1Cl)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Wang A, et al. Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.
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