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Rapamycin

CAS No. 53123-88-9

Rapamycin( Sirolimus )

Catalog No. M14886 CAS No. 53123-88-9

A macrolide compound that has potent immunosuppressive and antiproliferative properties by inhibiting mTOR (IC50=0.1 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 36 In Stock
50MG 43 In Stock
100MG 58 In Stock
200MG 99 In Stock
500MG 186 In Stock
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Biological Information

  • Product Name
    Rapamycin
  • Note
    Research use only, not for human use.
  • Brief Description
    A macrolide compound that has potent immunosuppressive and antiproliferative properties by inhibiting mTOR (IC50=0.1 nM).
  • Description
    A macrolide compound that has potent immunosuppressive and antiproliferative properties by inhibiting mTOR (IC50=0.1 nM).Other Indication Approved(In Vitro):Rapamycin (GMP) (1 nM; 2-3 weeks) induces in vitro differentiation of human embryonic stem cell (hESCs) into mineralized osteoblasts.Rapamycin (GMP) (1 nM; 2-3 weeks) enhances the osteoblastic differentiation of human embryoid bodies (hEBs).Rapamycin (GMP) (20 nM; 4 h) serum-dependently promotes vascular smooth muscle cells (VSMCs) differentiation.Rapamycin (GMP) induces osteoblastic differentiation in rat osteoblast-like osteosarcoma cells.
  • In Vitro
    Rapamycin (GMP) (1 nM; 2-3 weeks) induces in vitro differentiation of human embryonic stem cell (hESCs) into mineralized osteoblasts.Rapamycin (GMP) (1 nM; 2-3 weeks) enhances the osteoblastic differentiation of human embryoid bodies (hEBs).Rapamycin (GMP) (20 nM; 4 h) serum-dependently promotes vascular smooth muscle cells (VSMCs) differentiation.Rapamycin (GMP) induces osteoblastic differentiation in rat osteoblast-like osteosarcoma cells.
  • In Vivo
    ——
  • Synonyms
    Sirolimus
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    mTOR
  • Recptor
    mTOR
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    53123-88-9
  • Formula Weight
    914.1719
  • Molecular Formula
    C51H79NO13
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 28 mg/mL
  • SMILES
    C[C@@H](C([C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(C[C@@H]([C@H](C)C[C@@H]1CC[C@@H](O)C(OC)C1)OC2=O)=O)=O)C[C@H](C)/C=C/C=C/C=C(C)/[C@@H](OC)C[C@H]3O[C@](C(C(N4[C@H]2CCCC4)=O)=O)(O)[C@H](C)CC3
  • Chemical Name
    Rapamycin

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Morris RE, et al. Transplant Proc. 1991 Feb;23(1 Pt 1):521-4. 2. Dumont FJ, et al. J Immunol. 1990 Jan 1;144(1):251-8. 3. Dumont FJ, et al. J Immunol. 1990 Feb 15;144(4):1418-24. 4. Edwards SR, et al. J Biol Chem. 2007 May 4;282(18):13395-401.
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