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RWJ-49815

CAS No. 193282-45-0

RWJ-49815 ( RWJ 49815;RWJ49815 )

Catalog No. M13029 CAS No. 193282-45-0

A potent bactericidal agent that inhibits the KinA autophosphorylation with IC50 of 1.6 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    RWJ-49815
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent bactericidal agent that inhibits the KinA autophosphorylation with IC50 of 1.6 uM.
  • Description
    A potent bactericidal agent that inhibits the KinA autophosphorylation with IC50 of 1.6 uM; inhibits the autophosphorylation of kinase A of the KinA-Spo0F two-component signal transduction system in vitro; suppresses growth of MRSA, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus pneumoniae (MICs=1-2 ug/ml); exhibits reduced resistance emergence in a laboratory passage experiment compared with quinolone and ciprofloxacin.
  • Synonyms
    RWJ 49815;RWJ49815
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibacterial
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    193282-45-0
  • Formula Weight
    449.60
  • Molecular Formula
    C30H31N3O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    1-(4-(3,3,3-triphenylpropoxy)phenethyl)guanidine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Barrett JF, et al. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5317-22.
2. Stephenson K, et al. J Biol Chem. 2000 Dec 8;275(49):38900-4.
3. Theodorou EC, et al. Cell Signal. 2011 Aug;23(8):1327-37.
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