RU320521 ( RU.521 )

Catalog No. M20220 CAS No. 2262452-06-0

RU.521 (RU320521) is a potent?dsDNA?inhibitor (IC50 : 700?nM) inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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2MG	52	In Stock
5MG	87	In Stock
10MG	155	In Stock
25MG	253	In Stock
50MG	356	In Stock
100MG	530	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

RU320521
Note

Research use only not for human use.
Brief Description

RU.521 (RU320521) is a potent?dsDNA?inhibitor (IC50 : 700?nM) inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.
Description

RU.521 (RU320521) is a potent?dsDNA?inhibitor (IC50 : 700?nM) inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.
Synonyms

RU.521
Pathway

Cell Cycle/DNA Damage
Target

DNA/RNA Synthesis
Recptor

dsDNA/cGAS
Research Area

——
Indication

——

Chemical Information

CAS Number

2262452-06-0
Formula Weight

414.22
Molecular Formula

C19H11Cl2N4O3
Purity

>98% (HPLC)
Solubility

DMSO:125 mg/mL?(301.04 mM)
SMILES

Cc1nn(-c2nc3c(Cl)c(Cl)ccc3[nH]2)c(O)c1C1OC(=O)c2ccccc12
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Vincent J et al. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun. 2017 Sep 29;8(1):750.

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