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RU320521
CAS No. 2262452-06-0
RU320521( RU.521 )
Catalog No. M20220 CAS No. 2262452-06-0
RU.521 (RU320521) is a potent?dsDNA?inhibitor (IC50 : 700?nM) inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 52 | In Stock |
|
| 5MG | 87 | In Stock |
|
| 10MG | 155 | In Stock |
|
| 25MG | 253 | In Stock |
|
| 50MG | 356 | In Stock |
|
| 100MG | 530 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRU320521
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NoteResearch use only, not for human use.
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Brief DescriptionRU.521 (RU320521) is a potent?dsDNA?inhibitor (IC50 : 700?nM) inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.
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DescriptionRU.521 (RU320521) is a potent?dsDNA?inhibitor (IC50 : 700?nM) inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.
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In Vitro——
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In VivoAnimal Model:Male 8-week-old male mice with LPS injection Dosage:5 mg/kg Administration:Intraperitoneal injection; 5 mg/kg once Result:Increased cardiac function and reduced the inflammatory responses, oxidative stress and apoptosis in hearts of mice.
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SynonymsRU.521
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptordsDNA/cGAS
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Research Area——
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Indication——
Chemical Information
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CAS Number2262452-06-0
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Formula Weight414.22
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Molecular FormulaC19H11Cl2N4O3
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL?(301.04 mM)
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SMILESCc1nn(-c2nc3c(Cl)c(Cl)ccc3[nH]2)c(O)c1C1OC(=O)c2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Vincent J et al. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun. 2017 Sep 29;8(1):750.
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