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Home - Products - Cell Cycle/DNA Damage - DNA/RNA Synthesis - RU320521

RU320521

CAS No. 2262452-06-0

RU320521( RU.521 )

Catalog No. M20220 CAS No. 2262452-06-0

RU.521 (RU320521) is a potent?dsDNA?inhibitor (IC50 : 700?nM) inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 52 In Stock
5MG 87 In Stock
10MG 155 In Stock
25MG 253 In Stock
50MG 356 In Stock
100MG 530 In Stock
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Biological Information

  • Product Name
    RU320521
  • Note
    Research use only, not for human use.
  • Brief Description
    RU.521 (RU320521) is a potent?dsDNA?inhibitor (IC50 : 700?nM) inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.
  • Description
    RU.521 (RU320521) is a potent?dsDNA?inhibitor (IC50 : 700?nM) inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male 8-week-old male mice with LPS injection Dosage:5 mg/kg Administration:Intraperitoneal injection; 5 mg/kg once Result:Increased cardiac function and reduced the inflammatory responses, oxidative stress and apoptosis in hearts of mice.
  • Synonyms
    RU.521
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    dsDNA/cGAS
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2262452-06-0
  • Formula Weight
    414.22
  • Molecular Formula
    C19H11Cl2N4O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL?(301.04 mM)
  • SMILES
    Cc1nn(-c2nc3c(Cl)c(Cl)ccc3[nH]2)c(O)c1C1OC(=O)c2ccccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Vincent J et al. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun. 2017 Sep 29;8(1):750.
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