
RU320521
CAS No. 2262452-06-0
RU320521( RU.521 )
Catalog No. M20220 CAS No. 2262452-06-0
RU.521 (RU320521) is a potent?dsDNA?inhibitor (IC50 : 700?nM) inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 52 | In Stock |
![]() ![]() |
5MG | 87 | In Stock |
![]() ![]() |
10MG | 155 | In Stock |
![]() ![]() |
25MG | 253 | In Stock |
![]() ![]() |
50MG | 356 | In Stock |
![]() ![]() |
100MG | 530 | In Stock |
![]() ![]() |
200MG | Get Quote | In Stock |
![]() ![]() |
500MG | Get Quote | In Stock |
![]() ![]() |
1G | Get Quote | In Stock |
![]() ![]() |
Biological Information
-
Product NameRU320521
-
NoteResearch use only, not for human use.
-
Brief DescriptionRU.521 (RU320521) is a potent?dsDNA?inhibitor (IC50 : 700?nM) inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.
-
DescriptionRU.521 (RU320521) is a potent?dsDNA?inhibitor (IC50 : 700?nM) inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.
-
In Vitro——
-
In VivoAnimal Model:Male 8-week-old male mice with LPS injection Dosage:5 mg/kg Administration:Intraperitoneal injection; 5 mg/kg once Result:Increased cardiac function and reduced the inflammatory responses, oxidative stress and apoptosis in hearts of mice.
-
SynonymsRU.521
-
PathwayCell Cycle/DNA Damage
-
TargetDNA/RNA Synthesis
-
RecptordsDNA/cGAS
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2262452-06-0
-
Formula Weight414.22
-
Molecular FormulaC19H11Cl2N4O3
-
Purity>98% (HPLC)
-
SolubilityDMSO:125 mg/mL?(301.04 mM)
-
SMILESCc1nn(-c2nc3c(Cl)c(Cl)ccc3[nH]2)c(O)c1C1OC(=O)c2ccccc12
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Vincent J et al. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun. 2017 Sep 29;8(1):750.
molnova catalog



related products
-
SR 11302
SR 11302 is an inhibitor of activator protein-1 (AP-1).
-
ZIM
ZIM, a norbornene derivative of 4-Aminoantipyrine, effectively induces DNA damage, leading to genomic and chromosomal alterations, cell death, and phagocytosis activation.
-
5-DTTP Na3
Deoxythymidine-5'-triphosphate (dTTP) trisodium salt is one of the four natural deoxynucleotides. It is used for the biosynthesis of deoxyribonucleic acid by DNA polymerase and reverse transcriptase.