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RU-24969

CAS No. 66611-26-5

RU-24969( RU24969 | RU 24969 )

Catalog No. M15539 CAS No. 66611-26-5

A potent, selective agonist of 5-HT1A and 5-HT1B receptors, with preference for 5-HT1B.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    RU-24969
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective agonist of 5-HT1A and 5-HT1B receptors, with preference for 5-HT1B.
  • Description
    A potent, selective agonist of 5-HT1A and 5-HT1B receptors, with preference for 5-HT1B; inhibited the rate of synthesis of 5-HT in rat brain by about 50% (10mg/kg)
  • In Vitro
    RU 24969 (10 μM) reduces K+-stimulated release of [3H]-5-HT from ratfrontalcortex slices in vitro.
  • In Vivo
    RU 24969 (0.03-3.0 mg/kg; s.c.) dose-dependently decreases water consumption in water deprived rats.RU 24969 (0.3-3.0 mg/kg; s.c.) dose-dependently increases forward locomotion. Animal Model:Male Sprague-Dawley rats Dosage:0.03, 0.3, 1.0, 3.0 mg/kg Administration:A single s.c.Result:Decreased water consumption significantly at dose of 0.3, 1.0, and 3.0 mg/kg.
  • Synonyms
    RU24969 | RU 24969
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    66611-26-5
  • Formula Weight
    228.2896
  • Molecular Formula
    C14H16N2O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 30 mg/mL
  • SMILES
    COC1=CC2=C(NC=C2C3=CCNCC3)C=C1
  • Chemical Name
    1H-Indole, 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Green AR, et al. Neuropharmacology. 1984 Jun;23(6):655-61. 2. Harrison AA, et al. Psychopharmacology (Berl). 1999 Jan;141(3):242-50. 3. Parsons LH, et al. J Neurosci. 1998 Dec 1;18(23):10078-89.
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