RPI-1 ( RPI-1; RPI1; RPI 1 )

Catalog No. M17463 CAS No. 269730-03-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

RPI-1
Note

Research use only, not for human use.
Brief Description

RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.
Description

RPI-1 is an ATP-dependent RET kinase inhibitor. Oral treatment with RPI-1 caused growth arrest or regression in 81% treated tumors. Following treatment suspension, tumor inhibition was maintained (51%, P<0.05, 100 days) and cures were achieved in 2/11 mice. In vivo effects of RPI-1 were reflected in activation of BAD, cleavage of caspases, apoptotic DNA fragmentation and inhibition of VEGF production observed in in vitro RPI-1-treated TT cells..
Synonyms

RPI-1; RPI1; RPI 1
Pathway

Endocrinology/Hormones
Target

AChR
Recptor

Met; RET; CTND1; DCDB2; PLCγ
Research Area

——
Indication

——

CAS Number

269730-03-2
Formula Weight

297.31
Molecular Formula

C17H15NO4
Purity

98%
Solubility

——
SMILES

COc1c(cc2c(c1)/C(=C/c1ccc(cc1)O)/C(=O)N2)OC
Chemical Name

1,3-dihydro-3-[(4-hydroxyphenyl)methylene]-5,6-dimethoxy-2H-indol-2-one

1. Petrangolini G, et al. Biochem Pharmacol. 2006 Aug 14;72(4):405-14. 2. Caccia D, et al. Mol Y. 2010 Oct 18;9:278.

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