RPI-1
CAS No. 269730-03-2
RPI-1 ( RPI-1; RPI1; RPI 1 )
Catalog No. M17463 CAS No. 269730-03-2
RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 42 | In Stock |
|
10MG | 72 | In Stock |
|
25MG | 147 | In Stock |
|
50MG | 222 | In Stock |
|
100MG | 332 | In Stock |
|
500MG | 782 | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NameRPI-1
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NoteResearch use only, not for human use.
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Brief DescriptionRPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.
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DescriptionRPI-1 is an ATP-dependent RET kinase inhibitor. Oral treatment with RPI-1 caused growth arrest or regression in 81% treated tumors. Following treatment suspension, tumor inhibition was maintained (51%, P<0.05, 100 days) and cures were achieved in 2/11 mice. In vivo effects of RPI-1 were reflected in activation of BAD, cleavage of caspases, apoptotic DNA fragmentation and inhibition of VEGF production observed in in vitro RPI-1-treated TT cells..
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SynonymsRPI-1; RPI1; RPI 1
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PathwayEndocrinology/Hormones
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TargetAChR
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RecptorMet; RET; CTND1; DCDB2; PLCγ
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Research Area——
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Indication——
Chemical Information
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CAS Number269730-03-2
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Formula Weight297.31
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Molecular FormulaC17H15NO4
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Purity98%
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Solubility——
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SMILESCOc1c(cc2c(c1)/C(=C/c1ccc(cc1)O)/C(=O)N2)OC
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Chemical Name1,3-dihydro-3-[(4-hydroxyphenyl)methylene]-5,6-dimethoxy-2H-indol-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Petrangolini G, et al. Biochem Pharmacol. 2006 Aug 14;72(4):405-14. 2. Caccia D, et al. Mol Y. 2010 Oct 18;9:278.
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