RPI-1

CAS No. 269730-03-2

RPI-1 ( RPI-1; RPI1; RPI 1 )

Catalog No. M17463 CAS No. 269730-03-2

RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 42 In Stock
10MG 72 In Stock
25MG 147 In Stock
50MG 222 In Stock
100MG 332 In Stock
500MG 782 In Stock
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Biological Information

  • Product Name
    RPI-1
  • Note
    Research use only, not for human use.
  • Brief Description
    RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.
  • Description
    RPI-1 is an ATP-dependent RET kinase inhibitor. Oral treatment with RPI-1 caused growth arrest or regression in 81% treated tumors. Following treatment suspension, tumor inhibition was maintained (51%, P<0.05, 100 days) and cures were achieved in 2/11 mice. In vivo effects of RPI-1 were reflected in activation of BAD, cleavage of caspases, apoptotic DNA fragmentation and inhibition of VEGF production observed in in vitro RPI-1-treated TT cells..
  • Synonyms
    RPI-1; RPI1; RPI 1
  • Pathway
    Endocrinology/Hormones
  • Target
    AChR
  • Recptor
    Met; RET; CTND1; DCDB2; PLCγ
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    269730-03-2
  • Formula Weight
    297.31
  • Molecular Formula
    C17H15NO4
  • Purity
    98%
  • Solubility
    ——
  • SMILES
    COc1c(cc2c(c1)/C(=C/c1ccc(cc1)O)/C(=O)N2)OC
  • Chemical Name
    1,3-dihydro-3-[(4-hydroxyphenyl)methylene]-5,6-dimethoxy-2H-indol-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Petrangolini G, et al. Biochem Pharmacol. 2006 Aug 14;72(4):405-14. 2. Caccia D, et al. Mol Y. 2010 Oct 18;9:278.
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