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RP-54745

CAS No. 135330-08-4

RP-54745( —— )

Catalog No. M20324 CAS No. 135330-08-4

RP-54745 a potential antirheumatic compound. Inhibitor of macrophage stimulation and interleukin-1 production.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 177 In Stock
10MG 303 In Stock
25MG 515 In Stock
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Biological Information

  • Product Name
    RP-54745
  • Note
    Research use only, not for human use.
  • Brief Description
    RP-54745 a potential antirheumatic compound. Inhibitor of macrophage stimulation and interleukin-1 production.
  • Description
    RP-54745 a potential antirheumatic compound. Inhibitor of macrophage stimulation and interleukin-1 production.
  • In Vitro
    RP-54745 diminishes LPS-induced interleukin-1 (IL-1) production by murine peritoneal macrophages.
  • In Vivo
    RP-54745 (5 mg/kg) is effective at moderating oral doses in different mouse models of induced arthritis and in the MRL/lpr mice, genetically predisposed to develop an autoimmune pathology including arthritic disorders. The clinical status of the MRL mice, and several of their disturbed biochemical and immunological parameters, improved after a 3-month treatment with RP-54745.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    interleukin-1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    135330-08-4
  • Formula Weight
    297.8
  • Molecular Formula
    C13H12ClNOS2?
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:62.5 mg/mL?(209.86 mM)
  • SMILES
    CC1N(CCc2ccccc12)c1ssc(=O)c1Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Folliard F Bousseau A Terlain B . RP 54745 a potential antirheumatic compound. I. Inhibitor of macrophage stimulation and interleukin-1 production[J]. Agents and Actions 1992 36(1-2):119-126.
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