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RP-54745
CAS No. 135330-08-4
RP-54745( —— )
Catalog No. M20324 CAS No. 135330-08-4
RP-54745 a potential antirheumatic compound. Inhibitor of macrophage stimulation and interleukin-1 production.
RP-54745 a potential antirheumatic compound. Inhibitor of macrophage stimulation and interleukin-1 production.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 119 | In Stock |
|
| 5MG | 177 | In Stock |
|
| 10MG | 303 | In Stock |
|
| 25MG | 515 | In Stock |
|
| 50MG | 736 | In Stock |
|
| 100MG | 1017 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRP-54745
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NoteResearch use only, not for human use.
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Brief DescriptionRP-54745 a potential antirheumatic compound. Inhibitor of macrophage stimulation and interleukin-1 production.
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DescriptionRP-54745 a potential antirheumatic compound. Inhibitor of macrophage stimulation and interleukin-1 production.
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In VitroRP-54745 diminishes LPS-induced interleukin-1 (IL-1) production by murine peritoneal macrophages.
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In VivoRP-54745 (5 mg/kg) is effective at moderating oral doses in different mouse models of induced arthritis and in the MRL/lpr mice, genetically predisposed to develop an autoimmune pathology including arthritic disorders. The clinical status of the MRL mice, and several of their disturbed biochemical and immunological parameters, improved after a 3-month treatment with RP-54745.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptorinterleukin-1
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Research Area——
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Indication——
Chemical Information
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CAS Number135330-08-4
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Formula Weight297.8
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Molecular FormulaC13H12ClNOS2?
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Purity>98% (HPLC)
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SolubilityDMSO:62.5 mg/mL?(209.86 mM)
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SMILESCC1N(CCc2ccccc12)c1ssc(=O)c1Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Folliard F Bousseau A Terlain B . RP 54745 a potential antirheumatic compound. I. Inhibitor of macrophage stimulation and interleukin-1 production[J]. Agents and Actions 1992 36(1-2):119-126.
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