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RO5263397

CAS No. 1357266-05-7

RO5263397( —— )

Catalog No. M33107 CAS No. 1357266-05-7

RO5263397 is a TAAR1 specific agonist with oral activity that has been used in antidepressant studies.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 47 Get Quote
5MG 68 Get Quote
10MG 122 Get Quote
25MG 265 Get Quote
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Biological Information

  • Product Name
    RO5263397
  • Note
    Research use only, not for human use.
  • Brief Description
    RO5263397 is a TAAR1 specific agonist with oral activity that has been used in antidepressant studies.
  • Description
    RO5263397 is a potent, selective, and orally available TAAR1 agonist, with EC50s of 17 and 35 nM for human TAAR1 and rat TAAR1, respectively. RO5263397 regulates wakefulness and EEG spectral composition. Antidepressant-like effect.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Adult 4-5-month-old male WT littermates (C57BL/6 background) Dosage:0.1, 0.3, 1?mg/kg Administration:p.o.; dosing at the mid-light phase (ZT6)?Result:Increased wake time at 0.3 and 1?mg/kg
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1357266-05-7
  • Formula Weight
    194.21
  • Molecular Formula
    C10H11FN2O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 260 mg/mL (1338.76 mM; Ultrasonic )
  • SMILES
    Cc1c(F)cccc1[C@H]1COC(N)=N1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Galley G, et al. Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists.ACS Med Chem Lett.?2015 Dec 30;7(2):192-7.?
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