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RO3

CAS No. 1026582-88-6

RO3( —— )

Catalog No. M22083 CAS No. 1026582-88-6

RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    RO3
  • Note
    Research use only, not for human use.
  • Brief Description
    RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor.
  • Description
    RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor.
  • In Vitro
    ——
  • In Vivo
    In a guinea pig ureter-afferent nerve preparation, and mouse bladder-pelvic nerve preparation, RO-3 dose-dependently reduces afferent nerve activity induced by distension or α,β-meATP.RO-3 has activity in several rodent models of pain, as well as in cystometry models optimized to measure various parameters associated with sensory regulation of the micturition reflex.RO-3 has moderate to high metabolic stability in rat and human hepatocytes and liver microsomes, and is highly permeable, orally bioavailable (14%), and has a reasonable in vivo plasma half-life (t1/2=0.41?h) in rats.
  • Synonyms
    ——
  • Pathway
    Neuroscience
  • Target
    P2 Receptor
  • Recptor
    P2X3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1026582-88-6
  • Formula Weight
    302.38
  • Molecular Formula
    C16H22N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (413.40 mM)
  • SMILES
    COc1cc(Cc2cnc(N)nc2N)c(cc1OC)C(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Gever J R , Cockayne D A , Dillon M P , et al. Pharmacology of P2X channels[J]. Pflügers Archiv European Journal of Physiology, 2006, 452(5):513-37.
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