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RO1138452
CAS No. 221529-58-4
RO1138452 ( CAY10441 )
Catalog No. M17442 CAS No. 221529-58-4
RO1138452 is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3).
Purity : 96%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 57 | In Stock |
|
| 5MG | 87 | In Stock |
|
| 10MG | 140 | In Stock |
|
| 25MG | 312 | In Stock |
|
| 50MG | 537 | In Stock |
|
| 100MG | 767 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRO1138452
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NoteResearch use only, not for human use.
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Brief DescriptionRO1138452 is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3).
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DescriptionRO1138452 is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3). It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Likewise, it inhibits the binding of tritiated iloprost to rodent neuroblastoma cells with a Ki of about 1.5 nM. At levels between 2-20 mg/kg in rats, CAY10441 shows significant analgesic activity in standard antinociceptive assays.
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SynonymsCAY10441
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PathwayChromatin/Epigenetic
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TargetCOX
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Recptorprostacyclin receptor
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number221529-58-4
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Formula Weight309.41
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Molecular FormulaC19H23N3O
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Purity96%
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SolubilityDMSO : 33.33 mg/mL. 107.72 mM; H2O : < 0.1 mg/mL
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SMILESCC(C)Oc1ccc(Cc2ccc(NC3=NCCN3)cc2)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Clark R D, Jahangir A, Severance D, et al. Bioorganic & medicinal chemistry letters, 2004, 14(4): 1053-1056.
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