RNPA1000 ( RNPA-1000 )

Catalog No. M14235 CAS No. 359600-10-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

RNPA1000
Note

Research use only, not for human use.
Brief Description

RNPA1000 is a potent, specific small molecule inhibitor of S. aureus RnpA RNA degradation activity (IC50=100-125 uM).
Description

RNPA1000 is a potent, specific small molecule inhibitor of S. aureus RnpA RNA degradation activity (IC50=100-125 uM), limits S. aureus mRNA turnover and growth; does not affect the activity of the E. coli RNase HI, RNase A, RNase I or in-house purified S. aureus RNase J1 at 750 uM; also limits growth of other important Gram-positive bacterial pathogens, exhibits antimicrobial efficacy against biofilm associated S. aureus (S. aureus MRSA USA100 strain MIC=26 ug/mL) and protects against the S. aureus pathogenesis in an animal model of infection.
Synonyms

RNPA-1000
Pathway

GPCR/G Protein
Target

Antibacterial
Recptor

Antibacterial
Research Area

Infection
Indication

——

CAS Number

359600-10-5
Formula Weight

464.31
Molecular Formula

C23H18BrN3O3
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CC1=CC(=C(N1C2=CC=C(C=C2)C(=O)O)C)C=C(C#N)C(=O)NC3=CC(=CC=C3)Br
Chemical Name

Benzoic acid, 4-[3-[3-[(3-bromophenyl)amino]-2-cyano-3-oxo-1-propen-1-yl]-2,5-dimethyl-1H-pyrrol-1-yl]-

1. Olson PD, et al. PLoS Pathog. 2011 Feb 10;7(2):e1001287.
2. Eidem TM, et al.

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