RLX-33

CAS No. 2784577-71-3

RLX-33( —— )

Catalog No. M35682 CAS No. 2784577-71-3

RLX-33 is a potent and selective antagonist of relaxin family peptide 3 (RXFP3) that crosses the blood-brain barrier and also blocks relaxin 3-induced ERK1/2 phosphorylation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 114 Get Quote
5MG 178 Get Quote
10MG 283 Get Quote
25MG 437 Get Quote
50MG 624 Get Quote
100MG 821 Get Quote
500MG 1602 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    RLX-33
  • Note
    Research use only, not for human use.
  • Brief Description
    RLX-33 is a potent and selective antagonist of relaxin family peptide 3 (RXFP3) that crosses the blood-brain barrier and also blocks relaxin 3-induced ERK1/2 phosphorylation.
  • Description
    RLX-33 is a potent, selective and blood-brain barrier (BBB) penetrant relaxin family peptide 3 (RXFP3) antagonist, also blocks relaxin-3-induced ERK1/2 phosphorylation, with IC50 values of 2.36 μM for RXFP3, 7.82 and 13.86 μM for ERK1 and ERK2 phosphorylation, respectively. RLX-33 can block the stimulation of food intake induced by the RXFP3-selective agonist R3/I5 in rats. RLX-33 can be used for the research of metabolic syndrome.
  • In Vitro
    ——
  • In Vivo
    RLX-33 (10 mg/kg; IP, single dosage) attenuates the RXFP3-selective agonist R3/I5-induced increase in feeding in male Wistar rats.RLX-33 (10 mg/kg; IP, single dosage) exhibits a good brain penetration and highly protein-bound in rats plasma. Pharmacokinetic Parameters of RLX-33 in male Wistar rats (IP, 10 mg/kg).Animal Model:Male Wistar rats (intracerebroventricular administration of R3/I5 stimulated food intake Dosage:10 mg/kg Administration:IP, single dosage Result:Attenuated the R3/I5-induced increase in food intake.Animal Model:Male Wistar rats Dosage:10 mg/kg Administration:IP, single dosage (Pharmacokinetic Analysis)Result:Exhibited a good brain penetration and highly protein-bound, with protein binding of 99.8% in rat plasma.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    RXFP receptor | ERK
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2784577-71-3
  • Formula Weight
    462.89
  • Molecular Formula
    C24H19ClN4O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (270.04 mM; Ultrasonic )
  • SMILES
    N(C(=O)C1CN(CC2=CC=CO2)C(=O)C1)C3=CC=C(C4=NC(=NO4)C5=CC=C(Cl)C=C5)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. https://pubmed.ncbi.nlm.nih.gov/35594150/?
molnova catalog
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