
RLX-33
CAS No. 2784577-71-3
RLX-33( —— )
Catalog No. M35682 CAS No. 2784577-71-3
RLX-33 is a potent and selective antagonist of relaxin family peptide 3 (RXFP3) that crosses the blood-brain barrier and also blocks relaxin 3-induced ERK1/2 phosphorylation.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 114 | Get Quote |
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5MG | 178 | Get Quote |
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10MG | 283 | Get Quote |
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25MG | 437 | Get Quote |
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50MG | 624 | Get Quote |
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100MG | 821 | Get Quote |
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500MG | 1602 | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameRLX-33
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NoteResearch use only, not for human use.
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Brief DescriptionRLX-33 is a potent and selective antagonist of relaxin family peptide 3 (RXFP3) that crosses the blood-brain barrier and also blocks relaxin 3-induced ERK1/2 phosphorylation.
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DescriptionRLX-33 is a potent, selective and blood-brain barrier (BBB) penetrant relaxin family peptide 3 (RXFP3) antagonist, also blocks relaxin-3-induced ERK1/2 phosphorylation, with IC50 values of 2.36 μM for RXFP3, 7.82 and 13.86 μM for ERK1 and ERK2 phosphorylation, respectively. RLX-33 can block the stimulation of food intake induced by the RXFP3-selective agonist R3/I5 in rats. RLX-33 can be used for the research of metabolic syndrome.
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In Vitro——
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In VivoRLX-33 (10 mg/kg; IP, single dosage) attenuates the RXFP3-selective agonist R3/I5-induced increase in feeding in male Wistar rats.RLX-33 (10 mg/kg; IP, single dosage) exhibits a good brain penetration and highly protein-bound in rats plasma. Pharmacokinetic Parameters of RLX-33 in male Wistar rats (IP, 10 mg/kg).Animal Model:Male Wistar rats (intracerebroventricular administration of R3/I5 stimulated food intake Dosage:10 mg/kg Administration:IP, single dosage Result:Attenuated the R3/I5-induced increase in food intake.Animal Model:Male Wistar rats Dosage:10 mg/kg Administration:IP, single dosage (Pharmacokinetic Analysis)Result:Exhibited a good brain penetration and highly protein-bound, with protein binding of 99.8% in rat plasma.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorRXFP receptor | ERK
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Research Area——
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Indication——
Chemical Information
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CAS Number2784577-71-3
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Formula Weight462.89
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Molecular FormulaC24H19ClN4O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (270.04 mM; Ultrasonic )
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SMILESN(C(=O)C1CN(CC2=CC=CO2)C(=O)C1)C3=CC=C(C4=NC(=NO4)C5=CC=C(Cl)C=C5)C=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference



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