RK-33
CAS No. 1070773-09-9
RK-33 ( RK-33; RK 33; RK33. )
Catalog No. M17136 CAS No. 1070773-09-9
RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 59 | In Stock |
|
5MG | 106 | In Stock |
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10MG | 170 | In Stock |
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25MG | 356 | In Stock |
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50MG | 530 | In Stock |
|
100MG | 755 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NameRK-33
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NoteResearch use only, not for human use.
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Brief DescriptionRK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.
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DescriptionRK-33 is a potent and selective DDX3 inhibitor. RK-33 binds to DDX3 and abrogates its activity. Inhibition of DDX3 by RK-33 caused G1 cell cycle arrest, induced apoptosis, and promoted radiation sensitization in DDX3-overexpressing cells. Overall, inhibition of DDX3 by RK-33 promotes tumor regression, thus providing a compelling argument to develop DDX3 inhibitors for lung cancer therapy. RK-33 radiosensitizes prostate cancer cells by blocking the RNA helicase DDX3.
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SynonymsRK-33; RK 33; RK33.
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PathwayOthers
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TargetOther Targets
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RecptorDDX3
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1070773-09-9
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Formula Weight428.44
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Molecular FormulaC23H20N6O3
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Purity98%
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Solubility——
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SMILESCOC1=CC=C(C=C1)CN2C=NC3=C2N=CN=C4C3=NC(=O)N4CC5=CC=C(C=C5)OC
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Chemical Name3,7-dihydro-3,7-bis[(4-methoxyphenyl)methyl]-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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