RK-33 ( RK-33; RK 33; RK33. )

Catalog No. M17136 CAS No. 1070773-09-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

RK-33
Note

Research use only, not for human use.
Brief Description

RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.
Description

RK-33 is a potent and selective DDX3 inhibitor. RK-33 binds to DDX3 and abrogates its activity. Inhibition of DDX3 by RK-33 caused G1 cell cycle arrest, induced apoptosis, and promoted radiation sensitization in DDX3-overexpressing cells. Overall, inhibition of DDX3 by RK-33 promotes tumor regression, thus providing a compelling argument to develop DDX3 inhibitors for lung cancer therapy. RK-33 radiosensitizes prostate cancer cells by blocking the RNA helicase DDX3.
Synonyms

RK-33; RK 33; RK33.
Pathway

Others
Target

Other Targets
Recptor

DDX3
Research Area

Cancer
Indication

——

CAS Number

1070773-09-9
Formula Weight

428.44
Molecular Formula

C23H20N6O3
Purity

98%
Solubility

——
SMILES

COC1=CC=C(C=C1)CN2C=NC3=C2N=CN=C4C3=NC(=O)N4CC5=CC=C(C=C5)OC
Chemical Name

3,7-dihydro-3,7-bis[(4-methoxyphenyl)methyl]-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one