RK-33

CAS No. 1070773-09-9

RK-33 ( RK-33; RK 33; RK33. )

Catalog No. M17136 CAS No. 1070773-09-9

RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.

Purity : 98%

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 59 In Stock
5MG 106 In Stock
10MG 170 In Stock
25MG 356 In Stock
50MG 530 In Stock
100MG 755 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    RK-33
  • Note
    Research use only, not for human use.
  • Brief Description
    RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells.
  • Description
    RK-33 is a potent and selective DDX3 inhibitor. RK-33 binds to DDX3 and abrogates its activity. Inhibition of DDX3 by RK-33 caused G1 cell cycle arrest, induced apoptosis, and promoted radiation sensitization in DDX3-overexpressing cells. Overall, inhibition of DDX3 by RK-33 promotes tumor regression, thus providing a compelling argument to develop DDX3 inhibitors for lung cancer therapy. RK-33 radiosensitizes prostate cancer cells by blocking the RNA helicase DDX3.
  • Synonyms
    RK-33; RK 33; RK33.
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    DDX3
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1070773-09-9
  • Formula Weight
    428.44
  • Molecular Formula
    C23H20N6O3
  • Purity
    98%
  • Solubility
    ——
  • SMILES
    COC1=CC=C(C=C1)CN2C=NC3=C2N=CN=C4C3=NC(=O)N4CC5=CC=C(C=C5)OC
  • Chemical Name
    3,7-dihydro-3,7-bis[(4-methoxyphenyl)methyl]-2H-diimidazo[4,5-d:4',5'-f][1,3]diazepin-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
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