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RIPK2-IN-2

CAS No. 1581270-11-2

RIPK2-IN-2( RIPK2-IN-2 | RIPK2 IN 2 | RIPK2IN2 | RIPK2 inhibitor-2 | RIPK2 inhibitor 2 )

Catalog No. M12259 CAS No. 1581270-11-2

A potent, selective receptor interacting protein-2 (RIP2) kinase inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    RIPK2-IN-2
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective receptor interacting protein-2 (RIP2) kinase inhibitor.
  • Description
    A potent, selective receptor interacting protein-2 (RIP2) kinase inhibitor.
  • In Vitro
    RIP2 kinase inhibitor 2 is a novel prodrug of a quinazolyl amine that inhibits RIP2 kinase. Receptor interacting protein-2 (RIP2) kinase is a TKL family serine/threonine protein kinase involved in innate immune signaling. Following activation, RIP2 kinase associates with NODI or NOD2 and appears to function principally as a molecular scaffold to bring together other kinases (TAK1, ΙΚΚα/β/γ) involved in NF-κΒ and mitogen-activated protein kinase activation.
  • In Vivo
    ——
  • Synonyms
    RIPK2-IN-2 | RIPK2 IN 2 | RIPK2IN2 | RIPK2 inhibitor-2 | RIPK2 inhibitor 2
  • Pathway
    Apoptosis
  • Target
    RIP kinase
  • Recptor
    RIP kinase
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1581270-11-2
  • Formula Weight
    432.5364
  • Molecular Formula
    C21H28N4O4S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    COCCOC1=C(S(=O)(C(C)(C)C)=O)C=C2C(NC3=NNC(C)=C3C)=CC=NC2=C1
  • Chemical Name
    4-Quinolinamine, 6-[(1,1-dimethylethyl)sulfonyl]-N-(4,5-dimethyl-1H-pyrazol-3-yl)-7-(2-methoxyethoxy)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Linda N. Casillas, et al. Amino-quinolines as kinase inhibitors. PCT Int. Appl. (2014), WO 2014043437 A1 20140320.
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