Cart
sales@molnova.com
RAMX3
CAS No. 1397708-94-9
RAMX3( RAMX-3 | RAMX 3 )
Catalog No. M11660 CAS No. 1397708-94-9
A tritium-labeled allosteric modulator of the human chemokine receptor CXCR3 with Kd of 1.08 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameRAMX3
-
NoteResearch use only, not for human use.
-
Brief DescriptionA tritium-labeled allosteric modulator of the human chemokine receptor CXCR3 with Kd of 1.08 nM.
-
DescriptionA tritium-labeled allosteric modulator of the human chemokine receptor CXCR3 with Kd of 1.08 nM; radioligand displacement assays shows potent negative cooperativity between RAMX3 and chemokine CXCL11, providing a basis for the use of RAMX3 to investigate other potential allosteric modulators.
-
In Vitro——
-
In Vivo——
-
SynonymsRAMX-3 | RAMX 3
-
PathwayGPCR/G Protein
-
TargetChemokine Receptor
-
RecptorChemokine Receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1397708-94-9
-
Formula Weight631.693
-
Molecular FormulaC33H32T3F4N5O3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical NameN-(1-(3-(4-ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)ethyl)-2-(4-fluoro-3-(trifluoromethyl)phenyl)-N-((1-(methyl-t3)piperidin-4-yl)methyl)acetamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Bernat V, et al. ACS Chem Biol. 2014 Nov 21;9(11):2664-77.
2. Bernat V, et al. ChemMedChem. 2012 Aug;7(8):1481-9.
3. Milanos L, et al. Angew Chem Int Ed Engl. 2016 Dec 5;55(49):15277-15281.
molnova catalog
related products
-
SCH-527123
A potent, selective, orally bioavailable CXCR2/CXCR1 receptor antagonist with Kd of 0.08 and 41 nM for cynomolgus CXCR2 and CXCR1, respectively.
-
NVP-BDZ 824
A potent, highly selective antagonist of chemokine receptor CXCR3 with binding IC50 of 146 nM, Ca2+-mobilization IC50 of 28 nM.
-
CCX140
A potent, selective, orally bioavailable CCR2 antagonist with Kd of 2.3 nM for hCCR2.
