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Home - Products - Nuclear Receptor/Transcription Factor - Keap1-Nrf2 - RA-839

RA-839

CAS No. 1832713-02-6

RA-839( —— )

Catalog No. M34388 CAS No. 1832713-02-6

RA-839 is a potent small molecule Keap1 conjugate and selective Nrf2 signalling activator, as well as an inhibitor of Keap1/Nrf2 interaction with anticancer activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    RA-839
  • Note
    Research use only, not for human use.
  • Brief Description
    RA-839 is a potent small molecule Keap1 conjugate and selective Nrf2 signalling activator, as well as an inhibitor of Keap1/Nrf2 interaction with anticancer activity.
  • Description
    RA839 is a noncovalent small molecule binder to Keap1 with a Kd of ～6 μM and selective activator of Nrf2 signaling. RA839 prevents the induction of both inducible nitric-oxide synthase expression and nitric oxide release in response to lipopolysaccharides in macrophages. RA839 is a selective inhibitor of the Keap1/Nrf2 interaction and a useful tool compound to study the biology of Nrf2.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Nuclear Receptor/Transcription Factor
  • Target
    Keap1-Nrf2
  • Recptor
    Nrf2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1832713-02-6
  • Formula Weight
    452.57
  • Molecular Formula
    C25H28N2O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (220.96 mM; Ultrasonic )
  • SMILES
    Cc1cc(C)c(C)c(c1C)S(=O)(=O)Nc1ccc(N2CC[C@@H](C2)C(O)=O)c2ccccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Winkel AF, et al. Characterization of RA839, a Noncovalent Small Molecule Binder to Keap1 and Selective Activator of Nrf2 Signaling. J Biol Chem. 2015;290(47):28446-28455.?
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