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RA-839
CAS No. 1832713-02-6
RA-839( —— )
Catalog No. M34388 CAS No. 1832713-02-6
RA-839 is a potent small molecule Keap1 conjugate and selective Nrf2 signalling activator, as well as an inhibitor of Keap1/Nrf2 interaction with anticancer activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 126 | Get Quote |
|
| 10MG | 185 | Get Quote |
|
| 25MG | 299 | Get Quote |
|
| 50MG | 444 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameRA-839
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NoteResearch use only, not for human use.
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Brief DescriptionRA-839 is a potent small molecule Keap1 conjugate and selective Nrf2 signalling activator, as well as an inhibitor of Keap1/Nrf2 interaction with anticancer activity.
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DescriptionRA839 is a noncovalent small molecule binder to Keap1 with a Kd of ～6 μM and selective activator of Nrf2 signaling. RA839 prevents the induction of both inducible nitric-oxide synthase expression and nitric oxide release in response to lipopolysaccharides in macrophages. RA839 is a selective inhibitor of the Keap1/Nrf2 interaction and a useful tool compound to study the biology of Nrf2.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayNuclear Receptor/Transcription Factor
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TargetKeap1-Nrf2
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RecptorNrf2
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Research Area——
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Indication——
Chemical Information
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CAS Number1832713-02-6
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Formula Weight452.57
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Molecular FormulaC25H28N2O4S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (220.96 mM; Ultrasonic )
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SMILESCc1cc(C)c(C)c(c1C)S(=O)(=O)Nc1ccc(N2CC[C@@H](C2)C(O)=O)c2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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4-hydroxyphenyl acet...
4-Acetoxyphenol Prevents RPE Oxidative Stress-Induced Necrosis by Functioning as an NRF2 Stabilizer4-AC is a natural antioxidant, which demonstrates strong abilities to protect RPE cells from oxidative stress-induced necrosis.
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Nrf2-IN-1
Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML).Nrf2-IN-1 (Compound 4f), that inhibited Nrf2 activity.?4f had a profound growth-inhibitory effect on three AML cell lines, THP-1, HL-60 and U937, and a similar anti-growth effect in a chick embryo model.?
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Nrf2-IN-3
Nrf2-IN-3 is a mKEAP1-selective NRF2 inhibitor that selectively binds KEAP1 mutants and restores their NRF2 inhibitory function by repairing the disrupted KEAP1/NRF2 interaction, and selectively sensitizes cisplatin in xenografts of mouse mKEAP1 cancer cells.
