Cart
sales@molnova.com
R 59-022 hydrochloride
CAS No. 93076-98-3
R 59-022 hydrochloride( —— )
Catalog No. M36453 CAS No. 93076-98-3
R 59-022 hydrochloride (DKGI-I hydrochloride) is a 5-HT Receptor antagonist that activates protein kinase C (PKC).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 58 | In Stock |
|
| 5MG | 85 | In Stock |
|
| 10MG | 140 | In Stock |
|
| 25MG | 273 | In Stock |
|
| 50MG | 440 | In Stock |
|
| 100MG | 619 | In Stock |
|
| 500MG | 1278 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameR 59-022 hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionR 59-022 hydrochloride (DKGI-I hydrochloride) is a 5-HT Receptor antagonist that activates protein kinase C (PKC).
-
DescriptionR 59-022 (DKGI-I) hydrochloride is a DGK inhibitor (IC50: 2.8 μM). R 59-022 hydrochloride inhibits the phosphorylation of OAG to OAPA. R 59-022 hydrochloride is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 hydrochloride potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils.
-
In VitroWestern Blot Analysis Cell Line:HeLa cells Concentration:40 uM Incubation Time:30 min Result:Increased the phosphorylation of PKC downstream targets by about 2.5-fold.
-
In VivoAnimal Model:SCID mice implanted with U87 GBM cells Dosage:10 mg/kg Administration:Intraperitoneal injection (i.p.)Result:Increased median survival and decreased tumor volume.
-
Synonyms——
-
PathwayAngiogenesis
-
TargetPKC
-
RecptorPKC | 5-HT Receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number93076-98-3
-
Formula Weight496.04
-
Molecular FormulaC27H27ClFN3OS
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 25 mg/mL (50.40 mM; Ultrasonic )
-
SMILESCl.O=C1C(=C(N=C2SC=CN21)C)CCN3CCC(=C(C=4C=CC=CC4)C5=CC=C(F)C=C5)CC3
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. de Chaffoy de Courcelles, D.C., et al. R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet. J. Biol. Chem. 260(29), 15762-15770 (1985). ?
molnova catalog
related products
-
Protein kinase inhib...
Protein kinase inhibitor H-7 is a potent inhibitor of protein kinase C (PKC) with a Ki of 6 μM. Protein kinase inhibitor H-7 is also a cyclic nucleotide dependent protein kinase inhibitor.
-
CA-074 methyl ester
CA-074 methyl ester is a specific inhibitor of Cathepsin B with neuroprotective, anti-cancer, and anti-inflammatory effects.
-
PKC-iota inhibitor 1
PKC-iota inhibitor 1 is an inhibitor of protein kinase C-iota (PKC-ι ; IC50 : 0.34 μM).
