Cart
sales@molnova.com
Home - Products - Cell Cycle/DNA Damage - Potassium Channel - QO-40

QO-40

CAS No. 1259536-70-3

QO-40 ( —— )

Catalog No. M21936 CAS No. 1259536-70-3

QO-40 is a KCNQ2/3 potassium channels activator.QO-40 potently augmented KCNQ2/3 channels expressed in Chinese hamster ovary cells and shifted the half-maximal activation voltage (V(1/2)) in the hyperpolarizing direction.?The V(1/2) was negatively shifted in a concentration-dependent manner.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 45 In Stock
10MG 68 In Stock
25MG 122 In Stock
50MG 184 In Stock
100MG 275 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
Group Booking Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    QO-40
  • Note
    Research use only, not for human use.
  • Brief Description
    QO-40 is a KCNQ2/3 potassium channels activator.QO-40 potently augmented KCNQ2/3 channels expressed in Chinese hamster ovary cells and shifted the half-maximal activation voltage (V(1/2)) in the hyperpolarizing direction.?The V(1/2) was negatively shifted in a concentration-dependent manner.?
  • Description
    QO-40 is a KCNQ2/3 potassium channels activator.QO-40 potently augmented KCNQ2/3 channels expressed in Chinese hamster ovary cells and shifted the half-maximal activation voltage (V(1/2)) in the hyperpolarizing direction.?The V(1/2) was negatively shifted in a concentration-dependent manner.?The compounds markedly slowed both KCNQ2/3 channel activation and deactivation kinetics.?
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    KCNQ2/Q3 potassium channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1259536-70-3
  • Formula Weight
    377.75
  • Molecular Formula
    C18H11ClF3N3O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    FC(F)(F)c1nn4C(=O)C=C(Nc4c1c3cccc2ccccc23)CCl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jia C , Qi J , Zhang F , et al. Activation of KCNQ2/3 Potassium Channels by Novel Pyrazolo[1,5-a]pyrimidin-7(4H)-One Derivatives[J]. Pharmacology, 2011, 87(5-6):297-310.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • AUT1

    AUT1 (AUT-1) is a novel specific modulator of Kv3 channels (EC50: 4.7 and 4.9 uM for Kv3.1b and Kv3.2a).

  • Hydroquinidine

    Dihydroquinidine is an organic compound and as a cinchona alkaloid closely related to quinine.

  • ML277

    ML277 was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).

Sign In Join Free