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Q203

CAS No. 1334719-95-7

Q203 ( Q-203;Q 203;IAP6;Telacebec )

Catalog No. M11336 CAS No. 1334719-95-7

A novel potent anti-tuberculosis agent targeting cytochrome b subunit qcrB, inhibits M. tuberculosis H37Rv with MIC50 of of 2.7 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Q203
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel potent anti-tuberculosis agent targeting cytochrome b subunit qcrB, inhibits M. tuberculosis H37Rv with MIC50 of of 2.7 nM.
  • Description
    A novel potent anti-tuberculosis agent targeting cytochrome b subunit qcrB, inhibits M. tuberculosis H37Rv with MIC50 of of 2.7 nM; does not inhibit any of thecytochrome P450 (CYP450) isoenzymes; targets the respiratory cytochrome bc1 complex and triggers a rapid ATP depletion in M. tuberculosis, also inhibits the growth of MDR and XDR M. tuberculosis; deonstrates potency in mouse model of tuberculosis and displays pharmacokinetic and safety profiles.Bacterial Infection Phase 1 Clinical
  • Synonyms
    Q-203;Q 203;IAP6;Telacebec
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    MycobacteriumtuberculosisH37Rv
  • Research Area
    Infection
  • Indication
    Bacterial Infection

Chemical Information

  • CAS Number
    1334719-95-7
  • Formula Weight
    557.01
  • Molecular Formula
    C29H28ClF3N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10 mM
  • SMILES
    CCC1=C(N2C=C(C=CC2=N1)Cl)C(=O)NCC3=CC=C(C=C3)N4CCC(CC4)C5=CC=C(C=C5)OC(F)(F)F
  • Chemical Name
    Imidazo[1,2-a]pyridine-3-carboxamide, 6-chloro-2-ethyl-N-[[4-[4-[4-(trifluoromethoxy)phenyl]-1-piperidinyl]phenyl]methyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Pethe K, et al. Nat Med. 2013 Sep;19(9):1157-60.
2. Kang S, et al. J Med Chem. 2014 Jun 26;57(12):5293-305.
3. Jang J, et al. Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e02637-16.
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