Pyriproxyfen
CAS No. 95737-68-1
Pyriproxyfen ( S-31183 )
Catalog No. M26802 CAS No. 95737-68-1
Pyriproxyfen is an insecticide that acts as a biomimetic of juvenile hormone.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
500MG | 37 | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NamePyriproxyfen
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NoteResearch use only, not for human use.
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Brief DescriptionPyriproxyfen is an insecticide that acts as a biomimetic of juvenile hormone.
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DescriptionPyriproxyfen is an insecticide that acts as a biomimetic of juvenile hormone.(In Vivo):Zebrafish male adults were acutely exposed to 0.001, 0.01 and 0.1 μg/mL pyriproxyfen for 16 h. Mitochondrial respiration of brain tissues was assessed. ROS generation was estimated using H2DCF-DA and MitoSOX. Calcium transport was monitored by Calcium Green? 5 N. NO synthesis activity was estimated using DAF-FM-DA. Brain acetylcholinesterase showed an in vivo IC20 of 0.30 μmol/L pyriproxyfen, and an IC50 of 92.5 μmol/L. The inhibitory effect on zbAChE activity was competitive-like. Respiratory control of Complex I/II decreased significantly after insecticide exposure. The MitoSOX test showed that O2- generation had a pyriproxyfen dose-dependent effect. Brain tissue lost 50% of Ca2+ uptake capacity at 0.1 μg/mL pyriproxyfen. Ca2+ release showed a clear mitochondrial impairment at lower pyriproxyfen exposures.
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SynonymsS-31183
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PathwayOthers
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TargetOther Targets
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RecptorCDK4/CyclinD1
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Research Area——
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Indication——
Chemical Information
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CAS Number95737-68-1
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Formula Weight321.4
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Molecular FormulaC20H19NO3
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Purity>98% (HPLC)
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Solubility——
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SMILESCC(COc1ccc(Oc2ccccc2)cc1)Oc1ccccn1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Neel Jasani, et al. Potent anticancer activity of an orally bioavailable small molecule, ON 013100, and its water soluble derivative, briciclib, a clinical-stage eIF4E-targeted agent. AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA.
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