Pyriproxyfen

CAS No. 95737-68-1

Pyriproxyfen ( S-31183 )

Catalog No. M26802 CAS No. 95737-68-1

Pyriproxyfen is an insecticide that acts as a biomimetic of juvenile hormone.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
500MG 37 In Stock
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Biological Information

  • Product Name
    Pyriproxyfen
  • Note
    Research use only, not for human use.
  • Brief Description
    Pyriproxyfen is an insecticide that acts as a biomimetic of juvenile hormone.
  • Description
    Pyriproxyfen is an insecticide that acts as a biomimetic of juvenile hormone.(In Vivo):Zebrafish male adults were acutely exposed to 0.001, 0.01 and 0.1 μg/mL pyriproxyfen for 16 h. Mitochondrial respiration of brain tissues was assessed. ROS generation was estimated using H2DCF-DA and MitoSOX. Calcium transport was monitored by Calcium Green? 5 N. NO synthesis activity was estimated using DAF-FM-DA. Brain acetylcholinesterase showed an in vivo IC20 of 0.30 μmol/L pyriproxyfen, and an IC50 of 92.5 μmol/L. The inhibitory effect on zbAChE activity was competitive-like. Respiratory control of Complex I/II decreased significantly after insecticide exposure. The MitoSOX test showed that O2- generation had a pyriproxyfen dose-dependent effect. Brain tissue lost 50% of Ca2+ uptake capacity at 0.1 μg/mL pyriproxyfen. Ca2+ release showed a clear mitochondrial impairment at lower pyriproxyfen exposures.
  • Synonyms
    S-31183
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    CDK4/CyclinD1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    95737-68-1
  • Formula Weight
    321.4
  • Molecular Formula
    C20H19NO3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(COc1ccc(Oc2ccccc2)cc1)Oc1ccccn1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Neel Jasani, et al. Potent anticancer activity of an orally bioavailable small molecule, ON 013100, and its water soluble derivative, briciclib, a clinical-stage eIF4E-targeted agent. AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA.
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