Pyrimethamine ( Pirimecidan;Pirimetamin;RP 4753 )

Catalog No. M15132 CAS No. 58-14-0

A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

Pyrimethamine
Note

Research use only, not for human use.
Brief Description

A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties.
Description

A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties; interferes with the regeneration of tetrahydrofolic acid from dihydrofolate by competitively inhibiting DHFR; has also been found to reduce the expression of SOD1.Parasite Infection Approved
Synonyms

Pirimecidan;Pirimetamin;RP 4753
Pathway

Microbiology/Virology
Target

Parasite
Recptor

DHFR
Research Area

Infection
Indication

Parasite Infection

Chemical Information

CAS Number

58-14-0
Formula Weight

248.71
Molecular Formula

C12H13ClN4
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

CCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl
Chemical Name

2,4-Pyrimidinediamine, 5-(4-chlorophenyl)-6-ethyl-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Lange DJ, et al. Amyotroph Lateral Scler Frontotemporal Degener. 2013 Apr;14(3):199-204.
2. Wright PD, et al. Neurosci Lett. 2010 Oct 4;482(3):188-92.
3. Martins-Duarte éS, et al. Exp Parasitol. 2013 Mar;133(3):294-9.

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