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Pyrazoloacridine
CAS No. 99009-20-8
Pyrazoloacridine ( PD 115934; PD-115934; PD 115,934; NSC 366140; NSC-366140 )
Catalog No. M27918 CAS No. 99009-20-8
Pyrazoloacridine is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 132 | Get Quote |
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| 10MG | 215 | Get Quote |
|
| 25MG | 430 | Get Quote |
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| 50MG | 620 | Get Quote |
|
| 100MG | 884 | Get Quote |
|
| 500MG | 1764 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NamePyrazoloacridine
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NoteResearch use only, not for human use.
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Brief DescriptionPyrazoloacridine is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity.
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DescriptionPyrazoloacridine is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity.(In Vitro):In oxic and hypoxic HCT-8 cells, Pyrazoloacridine exhibits IC50 values of 10.7 μM and 4.5 μM. Pyrazoloacridine causes delayed DNA fragmentation in MCF-7 cells and induces apoptosis in P53-deficient Hep 3B cells. Pyrazoloacridine exhibits activities against cisplatin- and paclitaxel-resistant ovarian cancer.
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SynonymsPD 115934; PD-115934; PD 115,934; NSC 366140; NSC-366140
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PathwayApoptosis
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TargetApoptosis
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RecptorAkt;PP2A;Apoptosis;CIP2A
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Research Area——
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Indication——
Chemical Information
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CAS Number99009-20-8
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Formula Weight367.4
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Molecular FormulaC19H21N5O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCOc1ccc2[nH]c3c(ccc4n(CCCN(C)C)nc(c34)c2c1)[N+]([O-])=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Chun-Yu Liu, et al. EGFR-independent Elk1/CIP2A signalling mediates apoptotic effect of an erlotinib derivative TD52 in triple-negative breast cancer cells. Eur J Cancer. 2017 Feb;72:112-123.
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