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Pyrazoloacridine

CAS No. 99009-20-8

Pyrazoloacridine ( PD 115934; PD-115934; PD 115,934; NSC 366140; NSC-366140 )

Catalog No. M27918 CAS No. 99009-20-8

Pyrazoloacridine is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Pyrazoloacridine
  • Note
    Research use only, not for human use.
  • Brief Description
    Pyrazoloacridine is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity.
  • Description
    Pyrazoloacridine is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity.(In Vitro):In oxic and hypoxic HCT-8 cells, Pyrazoloacridine exhibits IC50 values of 10.7 μM and 4.5 μM. Pyrazoloacridine causes delayed DNA fragmentation in MCF-7 cells and induces apoptosis in P53-deficient Hep 3B cells. Pyrazoloacridine exhibits activities against cisplatin- and paclitaxel-resistant ovarian cancer.
  • Synonyms
    PD 115934; PD-115934; PD 115,934; NSC 366140; NSC-366140
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Akt;PP2A;Apoptosis;CIP2A
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    99009-20-8
  • Formula Weight
    367.4
  • Molecular Formula
    C19H21N5O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COc1ccc2[nH]c3c(ccc4n(CCCN(C)C)nc(c34)c2c1)[N+]([O-])=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Chun-Yu Liu, et al. EGFR-independent Elk1/CIP2A signalling mediates apoptotic effect of an erlotinib derivative TD52 in triple-negative breast cancer cells. Eur J Cancer. 2017 Feb;72:112-123.
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