Psoralen

Research use only, not for human use.

Psoralen is used as photochemical probe in studies of DNA mutation and repair mechanisms. Causes photosensitization in human.

Psoralen is used as photochemical probe in studies of DNA mutation and repair mechanisms. Causes photosensitization in human.(In Vitro):Psoralen (10-500 μM; 24-48 hours) inhibits cell viability in a concentration- and time-dependent manner in L02 and HepG2 cells. In L02 cells, Psoralen at 400 μM does not significantly change extracellular LDH levels, and 400 μM or 450 μM psoralen inhibits 50–60% of cell viability.Psoralen (150-450 μM; 24 hours) induces significant S-phase arrest in L02 cells in time- and dose-dependent manners, but it does not exhibits significant change in the cycle distribution of HepG2 cells.(In Vivo):Psoralen (oral gavage; 17.5 mg/kg; 6 weeks) reduces the number of metastatic lesions and the rate of bone metastasis by 20% compared to vehicle-treated mice. It also reduces tumor infiltration and decreases the percentage of tumor cells in metastatic lesions by ~40% compared to vehicle in mice.

Cell Proliferation Assay Cell Line:L02 and?HepG2 cells Concentration:10 μM, 50 μM,100 μM, 200 μM, 300 μM,400 μM,450 μM,500 μM Incubation Time:24 or 48 hours Result:Inhibited the viability of L02 and HepG2 cells mainly by suppressing cell proliferation rather than causing cell death. Cell Cycle Analysis Cell Line:L02 and?HepG2 cells Concentration:150 μM; 300 μM; 450 μM Incubation Time:24 or 48 hours Result:Induced cell S-phase arrest instead of causing cell apoptosis or death.

Animal Model:Female nude (BALB/c nu/nu) mice Dosage:17.5 mg/kg Administration:Oral gavage; 17.5 mg/kg; 6 weeks Result:Inhibited metastasis of breast cancer to bone in vivo.

Ficusin | Furocoumarin | NSC 404562

Others

Other Targets

Others

Cancer

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66-97-7

186.17

C11H6O3

>98% (HPLC)

DMSO: 10 mM

O=C1OC2=CC3=C(C=CO3)C=C2C=C1

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(-20℃)

With Ice Pack

≥ 2 years