
Prunetin
CAS No. 552-59-0
Prunetin( —— )
Catalog No. M18796 CAS No. 552-59-0
Prunetin significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 80 | In Stock |
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10MG | 140 | In Stock |
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25MG | 237 | In Stock |
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100MG | Get Quote | In Stock |
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Biological Information
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Product NamePrunetin
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NoteResearch use only, not for human use.
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Brief DescriptionPrunetin significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide.
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DescriptionPrunetin significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesity-related transcription through a feedback mechanism that regulates the expression of adiponectin, adipoR1, adipoR2, and AMPK. Prunetin and biochanin A are potent reducers of NF-κB and ERK activation, zonula occludens 1 tyrosine phosphorylation, and metalloproteinase-mediated shedding activity, which may account for the barrier-improving ability of these isoflavones. Prunetin significantly suppresses ATP-induced mucin secretion from cultured RTSE cells; Prunetin inhibits the production of MUC5AC mucin protein induced by EGF or PMA from NCI-H292 cells; Prunetin also inhibits the expression of MUC5AC mucin gene induced by EGF or PMA from NCI-H292 cells.
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In VitroPrunetin inhibited LPS-induced inflammatory cytokine production and MUC5?AC expression and secretion by inactivating the TLR4/MyD88 pathway in human nasal epithelial cells.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorNF-κB|ERK
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number552-59-0
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Formula Weight284.26
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Molecular FormulaC16H12O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (351.79 mM)
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SMILESCOC1=CC(=C2C(=C1)OC=C(C2=O)C3=CC=C(C=C3)O)O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog



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