
Prunetin
CAS No. 552-59-0
Prunetin( —— )
Catalog No. M18796 CAS No. 552-59-0
Prunetin significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 80 | In Stock |
![]() ![]() |
10MG | 140 | In Stock |
![]() ![]() |
25MG | 237 | In Stock |
![]() ![]() |
100MG | Get Quote | In Stock |
![]() ![]() |
200MG | Get Quote | In Stock |
![]() ![]() |
500MG | Get Quote | In Stock |
![]() ![]() |
1G | Get Quote | In Stock |
![]() ![]() |
Biological Information
-
Product NamePrunetin
-
NoteResearch use only, not for human use.
-
Brief DescriptionPrunetin significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide.
-
DescriptionPrunetin significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesity-related transcription through a feedback mechanism that regulates the expression of adiponectin, adipoR1, adipoR2, and AMPK. Prunetin and biochanin A are potent reducers of NF-κB and ERK activation, zonula occludens 1 tyrosine phosphorylation, and metalloproteinase-mediated shedding activity, which may account for the barrier-improving ability of these isoflavones. Prunetin significantly suppresses ATP-induced mucin secretion from cultured RTSE cells; Prunetin inhibits the production of MUC5AC mucin protein induced by EGF or PMA from NCI-H292 cells; Prunetin also inhibits the expression of MUC5AC mucin gene induced by EGF or PMA from NCI-H292 cells.
-
In VitroPrunetin inhibited LPS-induced inflammatory cytokine production and MUC5?AC expression and secretion by inactivating the TLR4/MyD88 pathway in human nasal epithelial cells.
-
In Vivo——
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorNF-κB|ERK
-
Research AreaOthers-Field
-
Indication——
Chemical Information
-
CAS Number552-59-0
-
Formula Weight284.26
-
Molecular FormulaC16H12O5
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (351.79 mM)
-
SMILESCOC1=CC(=C2C(=C1)OC=C(C2=O)C3=CC=C(C=C3)O)O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
molnova catalog



related products
-
1-Methyl-2-nonylquin...
1-Methyl-2-nonylquinolin-4(1H)-one has anti-inflammatory activity, it exhibits inhibitory activity on leukotriene biosynthesis in a bioassay using human polymorphonuclear granulocytes, with IC50 values of 12.1 microM.
-
MCH (salmon) TFA
Melanin Concentrating Hormone (MCH), a 19 amino acid cyclic peptide, is largely expressed in the hypothalamus. Melanin Concentrating Hormone is implicated in the control of general arousal and goal-orientated behaviours in mammals, and appears to be a key messenger in the regulation of food intake.
-
Mesosulfuron-methyl
Mesosulfuron-methyl is a systemic herbicide. It is used for post-emergence control of grasses and other weeds in cereals.