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Proxalutamide

CAS No. 1398046-21-3

Proxalutamide( GT-0918 | GT 0918 )

Catalog No. M11663 CAS No. 1398046-21-3

A potent androgen receptor (AR) antagonist with ability to down regulate AR protein level in prostate cancer cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Proxalutamide
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent androgen receptor (AR) antagonist with ability to down regulate AR protein level in prostate cancer cells.
  • Description
    A potent androgen receptor (AR) antagonist with ability to down regulate AR protein level in prostate cancer cells; more potently inhibits androgen binding with AR's ligand binding domain than Bicalutamide (11.4-fold) and MDV3100 (3.5-fold) in biochemical assay; demonstrates stronger potency to block AR function of gene transcription in CRPC cells; demonstrates good anti-tumor efficacy among hormone sensitive, CRPC and AR+ breast cancer animal models.Prostate Cancer Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    GT-0918 | GT 0918
  • Pathway
    Endocrinology/Hormones
  • Target
    Androgen Receptor (AR)
  • Recptor
    Androgen Receptor (AR)
  • Research Area
    Cancer
  • Indication
    Prostate Cancer

Chemical Information

  • CAS Number
    1398046-21-3
  • Formula Weight
    517.5
  • Molecular Formula
    C24H19F4N5O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N#CC1=CC=C(N(C(N(C2=CC=C(CCCC3=NC=CO3)N=C2)C4(C)C)=S)C4=O)C(F)=C1C(F)(F)F
  • Chemical Name
    4-[4,4-Dimethyl-3-[6-[3-(2-oxazolyl)propyl]-3-pyridinyl]-5-oxo-2-thioxo-1-imidazolidinyl]-3-fluoro-2-(trifluoromethyl)benzonitrile

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Youzhi Tong, et al. DOI: 10.1158/1538-7445.AM2014-614 Published October 2014 2. Yang M, et al. Int J Pharm. 2014 Nov 20;475(1-2):97-109.
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