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Protopine
CAS No. 130-86-9
Protopine( Protopine | Biflorine | Fumarine | Corydinine )
Catalog No. M17242 CAS No. 130-86-9
Protopine is a benzylisoquinoline alkaloid. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 64 | In Stock |
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| 5MG | 103 | In Stock |
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| 10MG | 152 | In Stock |
|
| 25MG | 319 | In Stock |
|
| 50MG | 568 | In Stock |
|
| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameProtopine
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NoteResearch use only, not for human use.
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Brief DescriptionProtopine is a benzylisoquinoline alkaloid. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic.
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DescriptionProtopine is discontinued (controlled substance). Protopine is a benzylisoquinoline alkaloid occurring in opium poppy, Corydalis tubers and other plants of the family papaveraceae, like Fumaria officinalis. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic.
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In VitroWestern Blot Analysis WB Cell Line:HepG2, Huh7 Concentration:10, 20, 40 μM Incubation Time:24 h Result:Induced the cleavage of caspase-3 and caspase-9.Decreased Bcl-2 and Bcl-xl level.Induced the release of mitochondrial protein cytochrome c into the cytosol.
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In VivoAnimal Model:5-hydroxy-DL-tryptophan (5-HTP)-induced mice modelDosage:5, 10, 20 mg/kg Administration:i.p.Result:Increased the number of 5-HTP-induced head twitch response (HTR).Decreased the immobility time tested in the Tail suspension test (TST).
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SynonymsProtopine | Biflorine | Fumarine | Corydinine
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PathwayPI3K/Akt/mTOR signaling
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TargetmTOR
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RecptorH1 receptor| platelet aggregation
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number130-86-9
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Formula Weight353.37
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Molecular FormulaC20H19NO5
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Purity>98% (HPLC)
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SolubilityDMSO : 12.5 mg/mL. 35.37 mM;
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SMILESCN1CCc2cc3c(cc2C(=O)Cc2c(C1)c1c(cc2)OCO1)OCO3
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Chemical Name7-Methyl-2,3:9,10-bis(methylenedioxy)-7,13a-secoberbin-13a-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Saeed SA, et al. Pharmacol Res. 1997 Jul;36(1):1-7.
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