Presatovir

CAS No. 1353625-73-6

Presatovir ( GS-5806 )

Catalog No. M22663 CAS No. 1353625-73-6

Presatovir (GS-5806) is a novel, orally bioavailable RSV fusion inhibitor (mean EC50: 0.43 nM).Presatovir exhibits potent activity against a wide range of RSV A and B clinical isolates (mean EC50: 0.43 nM) [1]. GS-5806 inhibits pre to post triggered conformational changes of RSV F protein, suggesting a possible mechanism for antiviral activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 237 In Stock
10MG 385 In Stock
25MG 644 In Stock
50MG 888 In Stock
100MG 1233 In Stock
500MG 2457 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Presatovir
  • Note
    Research use only, not for human use.
  • Brief Description
    Presatovir (GS-5806) is a novel, orally bioavailable RSV fusion inhibitor (mean EC50: 0.43 nM).Presatovir exhibits potent activity against a wide range of RSV A and B clinical isolates (mean EC50: 0.43 nM) [1]. GS-5806 inhibits pre to post triggered conformational changes of RSV F protein, suggesting a possible mechanism for antiviral activity.
  • Description
    Presatovir (GS-5806) is a novel, orally bioavailable RSV fusion inhibitor (mean EC50: 0.43 nM).Presatovir exhibits potent activity against a wide range of RSV A and B clinical isolates (mean EC50: 0.43 nM). GS-5806 inhibits pre to post triggered conformational changes of RSV F protein, suggesting a possible mechanism for antiviral activity.In a cotton rat model of RSV infection, Presatovir demonstrates dose-dependent (0-30 mg/kg) antiviral efficacy. Oral bioavailability in preclinical species ranges from 46 to 100%, with penetration of the compound into the lung tissue demonstrated in Sprague-Dawley rats. Multidose oral treatment of Presatovir appears safe in adults, and in healthy human volunteers experimentally infected with RSV, a potent antiviral effect and reduction in disease severity are observed in the high dose group.
  • Synonyms
    GS-5806
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    RSV
  • Research Area
    Infection
  • Indication
    Respiratory syncytial virus infections

Chemical Information

  • CAS Number
    1353625-73-6
  • Formula Weight
    532.06
  • Molecular Formula
    C24H29ClN7O3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:5 mg/mL (9.4 mM; Need ultrasonic and warming);Water:Insoluble
  • SMILES
    Cc1cn2nc(cc2nc1N1CC[C@H](N)C1)[C@@H]1CCCCN1C(=O)c1cc(Cl)ccc1NS(C)(=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mackman RL, et al. Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study. J Med Chem. 2015 Feb 26;58(4):1630-1643.
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