Presatovir
CAS No. 1353625-73-6
Presatovir ( GS-5806 )
Catalog No. M22663 CAS No. 1353625-73-6
Presatovir (GS-5806) is a novel, orally bioavailable RSV fusion inhibitor (mean EC50: 0.43 nM).Presatovir exhibits potent activity against a wide range of RSV A and B clinical isolates (mean EC50: 0.43 nM) [1]. GS-5806 inhibits pre to post triggered conformational changes of RSV F protein, suggesting a possible mechanism for antiviral activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 237 | In Stock |
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10MG | 385 | In Stock |
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25MG | 644 | In Stock |
|
50MG | 888 | In Stock |
|
100MG | 1233 | In Stock |
|
500MG | 2457 | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NamePresatovir
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NoteResearch use only, not for human use.
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Brief DescriptionPresatovir (GS-5806) is a novel, orally bioavailable RSV fusion inhibitor (mean EC50: 0.43 nM).Presatovir exhibits potent activity against a wide range of RSV A and B clinical isolates (mean EC50: 0.43 nM) [1]. GS-5806 inhibits pre to post triggered conformational changes of RSV F protein, suggesting a possible mechanism for antiviral activity.
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DescriptionPresatovir (GS-5806) is a novel, orally bioavailable RSV fusion inhibitor (mean EC50: 0.43 nM).Presatovir exhibits potent activity against a wide range of RSV A and B clinical isolates (mean EC50: 0.43 nM). GS-5806 inhibits pre to post triggered conformational changes of RSV F protein, suggesting a possible mechanism for antiviral activity.In a cotton rat model of RSV infection, Presatovir demonstrates dose-dependent (0-30 mg/kg) antiviral efficacy. Oral bioavailability in preclinical species ranges from 46 to 100%, with penetration of the compound into the lung tissue demonstrated in Sprague-Dawley rats. Multidose oral treatment of Presatovir appears safe in adults, and in healthy human volunteers experimentally infected with RSV, a potent antiviral effect and reduction in disease severity are observed in the high dose group.
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SynonymsGS-5806
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PathwayOthers
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TargetOther Targets
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RecptorRSV
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Research AreaInfection
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IndicationRespiratory syncytial virus infections
Chemical Information
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CAS Number1353625-73-6
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Formula Weight532.06
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Molecular FormulaC24H29ClN7O3S
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Purity>98% (HPLC)
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SolubilityDMSO:5 mg/mL (9.4 mM; Need ultrasonic and warming);Water:Insoluble
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SMILESCc1cn2nc(cc2nc1N1CC[C@H](N)C1)[C@@H]1CCCCN1C(=O)c1cc(Cl)ccc1NS(C)(=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mackman RL, et al. Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study. J Med Chem. 2015 Feb 26;58(4):1630-1643.
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