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Piragliatin

CAS No. 625114-41-2

Piragliatin( RO 4389620 | R-1440 )

Catalog No. M15367 CAS No. 625114-41-2

Piragliatin (RO 4389620;R-1440) is an allosteric, potent Glucokinase (GK) activator with SC1.5 of 0.18 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Piragliatin
  • Note
    Research use only, not for human use.
  • Brief Description
    Piragliatin (RO 4389620;R-1440) is an allosteric, potent Glucokinase (GK) activator with SC1.5 of 0.18 uM.
  • Description
    Piragliatin (RO 4389620;R-1440) is an allosteric, potent Glucokinase (GK) activator with SC1.5 of 0.18 uM; lowers pre- and postprandial glucose levels, improves the insulin secretory profile, increases β-cell sensitivity to glucose, and decreases hepatic glucose in vivo.Diabetes Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    RO 4389620 | R-1440
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Glucokinase
  • Recptor
    Glucokinase
  • Research Area
    Metabolic Disease
  • Indication
    Diabetes

Chemical Information

  • CAS Number
    625114-41-2
  • Formula Weight
    421.896
  • Molecular Formula
    C19H20ClN3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NC1=NC=CN=C1)[C@@H](C2=CC=C(S(=O)(C)=O)C(Cl)=C2)C[C@@H]3CC(CC3)=O
  • Chemical Name
    (2R)-2-(3-Chloro-4-(methylsulfonyl)phenyl)-3-((1R)-3-oxocyclopentyl)-N-pyrazinylpropanamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sarabu R, et al. J Med Chem. 2012 Aug 23;55(16):7021-36. 2. Bonadonna RC, et al. J Clin Endocrinol Metab. 2010 Nov;95(11):5028-36. 3. Zhi J, et al. J Clin Pharmacol. 2016 Feb;56(2):231-8. 4. Kim MK, et al. PLoS One. 2013 Sep 19;8(9):e73340.
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