
Pimonidazole
CAS No. 70132-50-2
Pimonidazole( —— )
Catalog No. M24717 CAS No. 70132-50-2
Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after the reduction of its nitro group.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
10MG | 35 | In Stock |
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25MG | 72 | In Stock |
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50MG | 138 | In Stock |
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100MG | 260 | In Stock |
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200MG | 356 | In Stock |
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500MG | Get Quote | In Stock |
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Biological Information
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Product NamePimonidazole
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NoteResearch use only, not for human use.
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Brief DescriptionPimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after the reduction of its nitro group.
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DescriptionPimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after the reduction of its nitro group. It can be used for qualitative and quantitative assessment of tumor hypoxia. Pimonidazole is a novel hypoxia marker for the complementary study of tumor hypoxia and cell proliferation in tumors.
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In VitroPimonidazole, the exogenous hypoxia marker, is a 2-nitroimidazole compound, which forms covalent bonds with cellular macromolecules at oxygen levels below 1.3%.Detection: Hypoxic cells were recognized by immunohistochemical detection of pimonidazole using a mouse monoclonal antibody. Cell proliferation was detected with a commercially available monoclonal antibody for proliferating cell nuclear antigen (PCNA). Assessment of hypoxia and cell proliferation was made qualitatively with light microscopy and quantitatively using point counting and image analysis software methods.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number70132-50-2
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Formula Weight254.29
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Molecular FormulaC11H18N4O3
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Purity>98% (HPLC)
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SolubilityH2O:1 mg/mL (3.93 mM; Need ultrasonic)
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SMILESOC(CN1C=CN=C1[N+]([O-])=O)CN2CCCCC2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Varia MA, et al. Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma. Gynecol Oncol. 1998 Nov;71(2):270-7.
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