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Phortress

CAS No. 328087-38-3

Phortress( NSC 710305 | NSC710305 )

Catalog No. M14071 CAS No. 328087-38-3

The L-lysylamide prodrug of 5F-203 (NSC703786), a potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 160 In Stock
25MG 267 In Stock
50MG 404 In Stock
100MG 597 In Stock
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Biological Information

  • Product Name
    Phortress
  • Note
    Research use only, not for human use.
  • Brief Description
    The L-lysylamide prodrug of 5F-203 (NSC703786), a potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway.
  • Description
    The L-lysylamide prodrug of 5F-203 (NSC703786), a potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway; causes MCF-7 sensitive cells to arrest in G(1) and S phase, and induces DNA adduct formation, in contrast to AhR-deficient AH(R100) variant MCF-7 cells, induces CYP1A1 and CYP1B1 transcription; demonstrats antitumor activity in vivo.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NSC 710305 | NSC710305
  • Pathway
    Endocrinology/Hormones
  • Target
    AhR
  • Recptor
    AhR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    328087-38-3
  • Formula Weight
    459.405
  • Molecular Formula
    C20H25Cl2FN4OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (272.09 mM)
  • SMILES
    CC1=C(C=CC(=C1)C2=NC3=C(S2)C=CC(=C3)F)NC(=O)C(CCCCN)N.Cl.Cl
  • Chemical Name
    (2S)-2,6-diamino-N-[4-(5-fluoro-1,3-benzothiazol-2-yl)-2-methylphenyl]hexanamide dihydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bradshaw TD, et al. Mol Cancer Ther. 2002 Feb;1(4):239-46. 2. Gilbert J, et al. Mol Pharmacol. 2017 Dec 21. pii: mol.117.109827. 3. Trapani V, et al. Br J Cancer. 2003 Feb 24;88(4):599-605. 4. Leong CO, et al. Br J Cancer. 2003 Feb 10;88(3):470-7.
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