Phortress

CAS No. 328087-38-3

Phortress( NSC 710305 | NSC710305 )

Catalog No. M14071 CAS No. 328087-38-3

The L-lysylamide prodrug of 5F-203 (NSC703786), a potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 88 In Stock
10MG 160 In Stock
25MG 267 In Stock
50MG 404 In Stock
100MG 597 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Phortress
  • Note
    Research use only, not for human use.
  • Brief Description
    The L-lysylamide prodrug of 5F-203 (NSC703786), a potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway.
  • Description
    The L-lysylamide prodrug of 5F-203 (NSC703786), a potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway; causes MCF-7 sensitive cells to arrest in G(1) and S phase, and induces DNA adduct formation, in contrast to AhR-deficient AH(R100) variant MCF-7 cells, induces CYP1A1 and CYP1B1 transcription; demonstrats antitumor activity in vivo.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NSC 710305 | NSC710305
  • Pathway
    Endocrinology/Hormones
  • Target
    AhR
  • Recptor
    AhR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    328087-38-3
  • Formula Weight
    459.405
  • Molecular Formula
    C20H25Cl2FN4OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (272.09 mM)
  • SMILES
    CC1=C(C=CC(=C1)C2=NC3=C(S2)C=CC(=C3)F)NC(=O)C(CCCCN)N.Cl.Cl
  • Chemical Name
    (2S)-2,6-diamino-N-[4-(5-fluoro-1,3-benzothiazol-2-yl)-2-methylphenyl]hexanamide dihydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Bradshaw TD, et al. Mol Cancer Ther. 2002 Feb;1(4):239-46. 2. Gilbert J, et al. Mol Pharmacol. 2017 Dec 21. pii: mol.117.109827. 3. Trapani V, et al. Br J Cancer. 2003 Feb 24;88(4):599-605. 4. Leong CO, et al. Br J Cancer. 2003 Feb 10;88(3):470-7.
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