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Phortress
CAS No. 328087-38-3
Phortress( NSC 710305 | NSC710305 )
Catalog No. M14071 CAS No. 328087-38-3
The L-lysylamide prodrug of 5F-203 (NSC703786), a potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 88 | In Stock |
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| 10MG | 160 | In Stock |
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| 25MG | 267 | In Stock |
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| 50MG | 404 | In Stock |
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| 100MG | 597 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePhortress
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NoteResearch use only, not for human use.
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Brief DescriptionThe L-lysylamide prodrug of 5F-203 (NSC703786), a potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway.
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DescriptionThe L-lysylamide prodrug of 5F-203 (NSC703786), a potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway; causes MCF-7 sensitive cells to arrest in G(1) and S phase, and induces DNA adduct formation, in contrast to AhR-deficient AH(R100) variant MCF-7 cells, induces CYP1A1 and CYP1B1 transcription; demonstrats antitumor activity in vivo.
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In Vitro——
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In Vivo——
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SynonymsNSC 710305 | NSC710305
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PathwayEndocrinology/Hormones
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TargetAhR
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RecptorAhR
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Research Area——
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Indication——
Chemical Information
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CAS Number328087-38-3
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Formula Weight459.405
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Molecular FormulaC20H25Cl2FN4OS
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (272.09 mM)
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SMILESCC1=C(C=CC(=C1)C2=NC3=C(S2)C=CC(=C3)F)NC(=O)C(CCCCN)N.Cl.Cl
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Chemical Name(2S)-2,6-diamino-N-[4-(5-fluoro-1,3-benzothiazol-2-yl)-2-methylphenyl]hexanamide dihydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bradshaw TD, et al. Mol Cancer Ther. 2002 Feb;1(4):239-46.
2. Gilbert J, et al. Mol Pharmacol. 2017 Dec 21. pii: mol.117.109827.
3. Trapani V, et al. Br J Cancer. 2003 Feb 24;88(4):599-605.
4. Leong CO, et al. Br J Cancer. 2003 Feb 10;88(3):470-7.
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