
Phloretin
CAS No. 60-82-2
Phloretin( NSC 407292 | RJC 02792 )
Catalog No. M18884 CAS No. 60-82-2
Phloretin is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
500MG | 51 | In Stock |
![]() ![]() |
1G | Get Quote | In Stock |
![]() ![]() |
Biological Information
-
Product NamePhloretin
-
NoteResearch use only, not for human use.
-
Brief DescriptionPhloretin is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport.
-
DescriptionPhloretin is a well-known inhibitor of eukaryotic urea transporters, blocks VacA-mediated urea and ion transport. Phloretin is a dihydrochalcone, a type of natural phenols. It can be found in apple tree leaves and the Manchurian apricot. It promotes potent antioxidative activities in peroxynitrite scavenging and the inhibition of lipid peroxidation. It has been found to inhibit the growth of several cancer cells and induce apoptosis of B16 melanoma and HL60 human leukemia cells.
-
In VitroApoptosis Analysis Cell Line:BEL-7402 cell Concentration:40-160 μM Incubation Time:24 hours Result:Induced cell apoptosis and activated caspase 3, 6 and 9.Western Blot AnalysisCell Line:3T3-L1 adipocytes Concentration:0 μM, 3 μM, 10 μM, 30 μM, 100 μM Incubation Time:24 hours Result:Inhibited PPAR-γ, C/EBPα and C/EBPβ expression. Western Blot Analysis Cell Line:3T3-L1 adipocytes Concentration:0 μM, 3 μM, 10 μM, 30 μM, 100 μM Incubation Time:24 hours Result:Upregulated the expression of p-ACC-1, p-AMPK, p-AMPKα and β .
-
In VivoAnimal Model:Collagen-Induced Arthritis (CIA) MiceDosage:50 or 100?mg/kg Administration:Oral adminstration Result:Showed mitigation of clinical symptoms of RA in addition to reduced inflammation of hind-limbs compared to the control group.
-
SynonymsNSC 407292 | RJC 02792
-
PathwayOthers
-
TargetOther Targets
-
RecptorSGLT1| SGLT2
-
Research AreaMetabolic Disease
-
Indication——
Chemical Information
-
CAS Number60-82-2
-
Formula Weight274.28
-
Molecular FormulaC15H14O5
-
Purity>98% (HPLC)
-
SolubilityDMSO : 50 mg/mL 182.30 mM; H2O : < 0.1 mg/mL
-
SMILESc1(c(c(cc(c1)O)O)C(=O)CCc1ccc(cc1)O)O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Chan SS, et al. Am J Physiol, 1962, 203, 975-979.
molnova catalog



related products
-
Isatidine
Isatidine is a pyrrolizidine alkaoid.
-
(E)-dec-3-enoic acid
(E)-dec-3-enoic acid (trans-3-decenoic acid) participates in the production of nanomaterials and can be used to study neurological diseases.
-
1-Amino-2-methylprop...
From Neurospora crassa.