Cart
sales@molnova.com
Home - Products - Metabolic Enzyme/Protease - Dehydrogenase - PfDHODH-IN-2

PfDHODH-IN-2

CAS No. 425629-94-3

PfDHODH-IN-2( —— )

Catalog No. M22750 CAS No. 425629-94-3

PfDHODH-IN-2 is a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH, IC50 : 1.11 μM) inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 147 Get Quote
10MG 222 Get Quote
25MG 410 Get Quote
50MG 605 Get Quote
100MG 860 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    PfDHODH-IN-2
  • Note
    Research use only, not for human use.
  • Brief Description
    PfDHODH-IN-2 is a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH, IC50 : 1.11 μM) inhibitor.
  • Description
    PfDHODH-IN-2 is a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH, IC50 : 1.11 μM) inhibitor .?It is used an antimalarial agent and can be used for the research of malaria.
  • In Vitro
    Malaria is a global parasitic infectious disease caused by Plasmodium parasites, among which Plasmodium falciparum is the most dangerous one with the highest rates of complications and mortality.PfDHODH-IN-2 shows an overall selectivity for PfDHODH (IC50=1.113 μM) over hDHODH (IC50>50 μM). PfDHODH-IN-2 demonstrats in vitro potency against the 3D7 and Dd2 strains of P. falciparum with IC50 values of both >20 μM, respectively in whole cell assays.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Dehydrogenase
  • Recptor
    PfDHODH
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    425629-94-3
  • Formula Weight
    297.76
  • Molecular Formula
    C13H12ClNO3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:12 mg/mL?(40.3 mM;?Need ultrasonic)
  • SMILES
    CCOC(=O)C1=C(Nc2ccc(Cl)cc2)SCC1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Minghao Xu, et al. Novel selective and potent inhibitors of malaria parasite dihydroorotate dehydrogenase: discovery and optimization of dihydrothiophenone derivatives. J Med Chem. 2013 Oct 24;56(20):7911-24.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • ALDH2 modulator 1

    ALDH2 modulator 1 is a potent, orally active modulator of acetaldehyde dehydrogenase-2 (ALDH2), which reduces blood alcohol levels in mice.

  • Taraxerone

    Taraxerone has allelopathic and antifungal effects.Taraxerone prevents catalase, superoxide dismutase, and reduces glutathione concentrations from the decrease induced by ethanol administration with the concentration dependent manner.

  • GSK321

    GSK321 is a selective and potent mutant isocitrate dehydrogenase 1 (IDH1) inhibitor that inhibits lipid synthesis and blocks cell proliferation in OPA1-deficient MEFs and prevents cytoplasmic glutamine reductive carboxylation.GSK321 has been used in the study of leukemia.

Sign In Join Free