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Perlapine

CAS No. 1977-11-3

Perlapine ( AW-14233;HF-2333;Hypnodine )

Catalog No. M13091 CAS No. 1977-11-3

Perlapine (AW-14233;HF-2333;Hypnodine) is a potent antihistamine that has high affinity for dopamine D1, α1, α2 and 5-HT2A receptors.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Perlapine
  • Note
    Research use only, not for human use.
  • Brief Description
    Perlapine (AW-14233;HF-2333;Hypnodine) is a potent antihistamine that has high affinity for dopamine D1, α1, α2 and 5-HT2A receptors.
  • Description
    Perlapine (AW-14233;HF-2333;Hypnodine) is a potent antihistamine that has high affinity for dopamine D1, α1, α2 and 5-HT2A receptors with IC50 of 198, 19, 4945 and 70 nM, respectively; also has anticholinergic, antiserotonergic, antiadrenergic and antidopaminergic activity; also is a highly potent hM3Dq agonist (EC50=2.8 nM) but do not activate the native human M3 receptor (hM3, EC50>30 uM).
  • Synonyms
    AW-14233;HF-2333;Hypnodine
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1977-11-3
  • Formula Weight
    291.40
  • Molecular Formula
    C19H21N3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CN1CCN(C2=NC3=CC=CC=C3CC4=CC=CC=C42)CC1
  • Chemical Name
    6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Stille G, et al. Psychopharmacologia. 1973 Feb 20;28(4):325-37.
2. Wilk S, et al. Eur J Pharmacol. 1977 Jan 7;41(1):65-72.
3. Chen X, et al. ACS Chem Neurosci. 2015 Mar 18;6(3):476-84.
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