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Perlapine
CAS No. 1977-11-3
Perlapine( AW-14233 | HF-2333 | Hypnodine )
Catalog No. M13091 CAS No. 1977-11-3
Perlapine (AW-14233;HF-2333;Hypnodine) is a potent antihistamine that has high affinity for dopamine D1, α1, α2 and 5-HT2A receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePerlapine
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NoteResearch use only, not for human use.
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Brief DescriptionPerlapine (AW-14233;HF-2333;Hypnodine) is a potent antihistamine that has high affinity for dopamine D1, α1, α2 and 5-HT2A receptors.
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DescriptionPerlapine (AW-14233;HF-2333;Hypnodine) is a potent antihistamine that has high affinity for dopamine D1, α1, α2 and 5-HT2A receptors with IC50 of 198, 19, 4945 and 70 nM, respectively; also has anticholinergic, antiserotonergic, antiadrenergic and antidopaminergic activity; also is a highly potent hM3Dq agonist (EC50=2.8 nM) but do not activate the native human M3 receptor (hM3, EC50>30 uM).
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In Vitro——
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In Vivo——
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SynonymsAW-14233 | HF-2333 | Hypnodine
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1977-11-3
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Formula Weight291.398
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Molecular FormulaC19H21N3
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Purity>98% (HPLC)
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Solubility——
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SMILESCN1CCN(C2=NC3=CC=CC=C3CC4=CC=CC=C42)CC1
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Chemical Name6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Stille G, et al. Psychopharmacologia. 1973 Feb 20;28(4):325-37.
2. Wilk S, et al. Eur J Pharmacol. 1977 Jan 7;41(1):65-72.
3. Chen X, et al. ACS Chem Neurosci. 2015 Mar 18;6(3):476-84.
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