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Pelitinib
CAS No. 257933-82-7
Pelitinib( EKB-569 | WAY-EKB 569 | EKB569 | EKB 569 )
Catalog No. M13779 CAS No. 257933-82-7
A potent, selective, orally active, irreversible inhibitor of EGFR with IC50 of 80 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 39 | In Stock |
|
| 10MG | 55 | In Stock |
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| 25MG | 96 | In Stock |
|
| 50MG | 120 | In Stock |
|
| 100MG | 178 | In Stock |
|
| 500MG | 441 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePelitinib
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, orally active, irreversible inhibitor of EGFR with IC50 of 80 nM.
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DescriptionA potent, selective, orally active, irreversible inhibitor of EGFR with IC50 of 80 nM; inhibits autophosphorylation of the cytoplasmic domain of HER-2 with IC50 of 1.23 uM; shows 1-3 orders of magnitude higher IC50 value for Src, Cdk4, c-Met, Raf, and MEK/ERK; inhibits proliferation in NHEK, A431, and MDA-468 cells (IC50= 61, 125, and 260 nM, respectively); potently inhibits the EGFR phosphorylation in A431 xenografts, suppresses tumorigenesis in APCMin/+ mice.Lung Cancer Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsEKB-569 | WAY-EKB 569 | EKB569 | EKB 569
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR|HER2/ErbB2|MEK|Raf|Src
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Research AreaCancer
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IndicationLung Cancer
Chemical Information
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CAS Number257933-82-7
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Formula Weight467.9231
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Molecular FormulaC24H23ClFN5O2
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Purity>98% (HPLC)
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SolubilityDMSO: 16 mg/mL
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SMILESO=C(NC1=C(OCC)C=C2N=CC(C#N)=C(NC3=CC=C(F)C(Cl)=C3)C2=C1)/C=C/CN(C)C
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Chemical Name2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-, (2E)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wissner A, et al. J Med Chem. 2003 Jan 2;46(1):49-63.
2. Nunes M, et al. Mol Cancer Ther. 2004 Jan;3(1):21-7.
3. Torrance CJ, et al. Nat Med. 2000 Sep;6(9):1024-8.
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