Cart
sales@molnova.com
Pelitinib
CAS No. 257933-82-7
Pelitinib ( EKB-569;WAY-EKB 569;EKB569;EKB 569 )
Catalog No. M13779 CAS No. 257933-82-7
A potent, selective, orally active, irreversible inhibitor of EGFR with IC50 of 80 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 39 | In Stock |
|
| 10MG | 55 | In Stock |
|
| 25MG | 96 | In Stock |
|
| 50MG | 120 | In Stock |
|
| 100MG | 178 | In Stock |
|
| 500MG | 441 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePelitinib
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective, orally active, irreversible inhibitor of EGFR with IC50 of 80 nM.
-
DescriptionA potent, selective, orally active, irreversible inhibitor of EGFR with IC50 of 80 nM; inhibits autophosphorylation of the cytoplasmic domain of HER-2 with IC50 of 1.23 uM; shows 1-3 orders of magnitude higher IC50 value for Src, Cdk4, c-Met, Raf, and MEK/ERK; inhibits proliferation in NHEK, A431, and MDA-468 cells (IC50= 61, 125, and 260 nM, respectively); potently inhibits the EGFR phosphorylation in A431 xenografts, suppresses tumorigenesis in APCMin/+ mice.Lung Cancer Phase 2 Clinical
-
SynonymsEKB-569;WAY-EKB 569;EKB569;EKB 569
-
PathwayAngiogenesis
-
TargetEGFR
-
RecptorEGFR;HER2/ErbB2;MEK;Raf;Src
-
Research AreaCancer
-
IndicationLung Cancer
Chemical Information
-
CAS Number257933-82-7
-
Formula Weight467.92
-
Molecular FormulaC24H23ClFN5O2
-
Purity>98% (HPLC)
-
SolubilityDMSO: 16 mg/mL
-
SMILESO=C(NC1=C(OCC)C=C2N=CC(C#N)=C(NC3=CC=C(F)C(Cl)=C3)C2=C1)/C=C/CN(C)C
-
Chemical Name2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-, (2E)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Wissner A, et al. J Med Chem. 2003 Jan 2;46(1):49-63.
2. Nunes M, et al. Mol Cancer Ther. 2004 Jan;3(1):21-7.
3. Torrance CJ, et al. Nat Med. 2000 Sep;6(9):1024-8.
2. Nunes M, et al. Mol Cancer Ther. 2004 Jan;3(1):21-7.
3. Torrance CJ, et al. Nat Med. 2000 Sep;6(9):1024-8.
molnova catalog
related products
-
AZD8931 diFuMaric ac...
AZD8931 is a reversible and ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 (IC50 of 4 nM, 3 nM and 4 nM, respectively).AZD8931 significantly suppressed cell growth of IBC cells and induced apoptosis of human IBC cells in vitro.AZD8931 monotherapy inhibited xenograft growth.
-
Epertinib hydrochlor...
Epertinib hydrochloride shows potent antitumor activity.?
-
Lifirafenib
Lifirafenib is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant respectively.
