
Panaxadiol
CAS No. 19666-76-3
Panaxadiol( 20(R)-Panaxadiol )
Catalog No. M18191 CAS No. 19666-76-3
Panaxadiol is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.
Purity : >98% (HPLC)






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Biological Information
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Product NamePanaxadiol
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NoteResearch use only, not for human use.
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Brief DescriptionPanaxadiol is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.
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DescriptionPanaxadiol is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.
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In VitroPanaxadiol (1-10 μM, 12 h) inhibits PD-L1 expression in human colon cancer cells.Panaxadiol (1-10 μM, 12 h) inhibits the expression of PD-L1 by suppressing HIF-1α and STAT3 in HCT116 cells. Western Blot AnalysisCell Line:HCT116, SW620 and HT-29 colon cancer cells Concentration:1, 3, and 10 μM Incubation Time:12 hours Result:Decreased the expression of PD-L1 protein and mRNA in a dose-dependent manner.Western Blot Analysis Cell Line:HCT116 cells Concentration:1, 3, and 10 μM Incubation Time:12 hours Result:Inhibited hypoxia-induced nuclear accumulation of HIF-1α in a dose-dependent manner.Inhibited STAT3 phosphorylation at Tyr705 in a dose-dependent manner under both normoxic and hypoxic conditions.
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In VivoPanaxadiol (oral gavage; 10 or 30 mg/kg; once every 3 days; 30 d) inhibits the growth of HCT116 cells in a xenograft model. Animal Model:BALB/c athymic nude mice injected with HCT116 cells Dosage:10 or 30 mg/kg Administration:Oral gavage; 10 or 30 mg/kg; once every 3 days; 30 days Result:Inhibited the protein levels of HIF-1α, p-STAT-3 (Tyr705), PD-L1 and VEGF in tumour tissues in a dose-dependent manner.
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Synonyms20(R)-Panaxadiol
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number19666-76-3
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Formula Weight460.73
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Molecular FormulaC30H52O3
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Purity>98% (HPLC)
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SolubilityEthanol : 20 mg/mL 43.41 mM;
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SMILESO[C@H]1[C@H]2[C@]([C@]3([C@@H]([C@@]4([C@@H](CC3)C([C@@H](O)CC4)(C)C)C)C1)C)(CC[C@@H]2[C@@]1(OC(CCC1)(C)C)C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lin X, et al. Exp Hematol. 2015 May;43(5):364-73.
molnova catalog



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