PXS-5153A
CAS No. 2125956-82-1
PXS-5153A ( —— )
Catalog No. M26400 CAS No. 2125956-82-1
PXS-5153A is an effective, selective, and fast-acting inhibitor of lysyl oxidase like 2/3 enzymes with enzymatic activity almost entirely blocked within 15 minutes. PXS-5153A could reduce crosslinks and ameliorates fibrosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 393 | Get Quote |
|
10MG | 581 | Get Quote |
|
25MG | 888 | Get Quote |
|
50MG | 1242 | Get Quote |
|
100MG | 1674 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NamePXS-5153A
-
NoteResearch use only, not for human use.
-
Brief DescriptionPXS-5153A is an effective, selective, and fast-acting inhibitor of lysyl oxidase like 2/3 enzymes with enzymatic activity almost entirely blocked within 15 minutes. PXS-5153A could reduce crosslinks and ameliorates fibrosis.
-
DescriptionPXS-5153A is an effective, selective, and fast-acting inhibitor of lysyl oxidase like 2/3 enzymes with enzymatic activity almost entirely blocked within 15 minutes. PXS-5153A could reduce crosslinks and ameliorates fibrosis.(In Vitro):PXS-5153A is >40-fold selective for LOXL2 over both LOX and LOXL1 and >700-fold selective over other related amine oxidases. PXS-5153A exhibits an IC50 of <40 nM for LOXL2 across all mammalian species tested. PXS-5153A also inhibits human LOXL3 with an IC50 value of 63 nM.(In Vivo):rhLOXL2 dose-dependently induces oxidation of collagen with PXS-5153A dose-dependently impeding collagen oxidation. Therapeutic treatment of PXS-5153A substantially reduces immature crosslink formation compared with the CCl4 treated animals. Mature crosslink formation is also reduced by PXS-5153A treatment. All groups with therapeutic treatment of PXS-5153A show a significant reduction in DHLNL formation and HYP compared to the CCl4 treated animals.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
Recptor——
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2125956-82-1
-
Formula Weight475.4
-
Molecular FormulaC20H25Cl2FN4O2S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESCl.Cl.CN(C)S(=O)(=O)c1cccc(c1)-c1c(C)n(C\C(F)=C\CN)c2cccnc12
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
molnova catalog
related products
-
5-TAMRA chloride(918...
5-TAMRA can produce bright, pH insensitive orange fluorescence (Ex/ Em= 546 / 579nm), and has good photostability
-
GIP (1-39)
Endogenous truncated form of the incretin hormone GIP. More potent at stimulating glucose-dependent insulin secretion from rat pancreatic β-cells than GIP.
-
Ganoderic acid J
Ganoderic acid J, a natural terpenoid extracted from Ganoderma lucidum fungus, exhibits anti-inflammatory properties.